Aktuelle Aspekte der radioonkologischen Behandlung lokal fortgeschrittener Kopf-Hals-Tumoren

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• 作者：Dr. S.U. Pigorsch (1)
  M.N. Duma (1)
  
• 关键词：Kopf ; Hals ; Tumoren ; Intensit盲tsmodulierte Strahlentherapie ; Bildgesteuerte Strahlentherapie ; Radiochemotherapie ; Humane Papillomaviren ; Head and neck cancer ; Intensity modulated radiotherapy ; Image ; guided radiation therapy ; Chemoradiotherapy ; Human papillomavirus
• 刊名：Der Onkologe
• 出版年：2014
• 出版时间：February 2014
• 年：2014
• 卷：20
• 期：2
• 页码：139-143
• 全文大小：328 KB
• 作者单位：Dr. S.U. Pigorsch (1)
  M.N. Duma (1)
  
  1. Klinik und Poliklinik f眉r Strahlentherapie und Radiologische Onkologie, Technische Universit盲t M眉nchen, Klinikum rechts der Isar, Ismaninger Str. 22, 81675, M眉nchen, Deutschland
  
• ISSN：1433-0415

文摘

Background Concomitant chemo-irradiation is one of the main components in the treatment of locally advanced head and neck cancer. Over the last decade the development of intensity modulated radiotherapy (IMRT) has been rapidly implemented in the treatment of patients with head and neck cancer. Objectives Treatment recommendations for locally advanced head and neck cancer are given based on the results of radio-oncological meta-analyses. Strategies for organ and function preservation as well as human papillomavirus (HPV) positive tumors are discussed. Recent technological progress in radiation oncology will be briefly explained. Materials and methods The study included research and analysis of the literature and published results of clinical trials and meta-analyses. Results and conclusion The concomitant platinum-based chemo-irradiation is the state of the art treatment for locally advanced head and neck cancer. If there are contraindications for concomitant chemo-irradiation the fractionation schedule (hyperfractionation) should be changed. Induction chemotherapy (iCT) is seen at the moment as experimental and should only be used in controlled trials. Concerning HPV positive tumors there is still no evidence to support changes in the standard treatment regimen.