Management Strategies for Locoregional Recurrence in Early-Stage Gastric Cancer: Retrospective Analysis and Comprehensive Literature Review

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• 作者：Ahmed Salem (1)
  Sameh Hashem (1)
  Layth Y. I. Mula-Hussain (1)
  Issa Mohammed (1)
  Ala’a Nour (1)
  Wael Shelpai (2)
  Faiez Daoud (3)
  Basem Morcos (3)
  Yasser Yamin (4)
  Imad Jaradat (1)
  Jamal Khader (1)
  Abdelatief Almousa (1)
  
• 关键词：Gastric cancer ; Recurrence ; Radiotherapy ; Surgery ; Chemotherapy
• 刊名：Journal of Gastrointestinal Cancer
• 出版年：2012
• 出版时间：March 2012
• 年：2012
• 卷：43
• 期：1
• 页码：77-82
• 全文大小：131KB
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• 作者单位：Ahmed Salem (1)
  Sameh Hashem (1)
  Layth Y. I. Mula-Hussain (1)
  Issa Mohammed (1)
  Ala’a Nour (1)
  Wael Shelpai (2)
  Faiez Daoud (3)
  Basem Morcos (3)
  Yasser Yamin (4)
  Imad Jaradat (1)
  Jamal Khader (1)
  Abdelatief Almousa (1)
  
  1. Department of Radiation Oncology, King Hussein Cancer Center, Amman, Jordan
  2. Clinical Research and Cancer Registry, King Hussein Cancer Center, Amman, Jordan
  3. Department of Surgical Oncology, King Hussein Cancer Center, Amman, Jordan
  4. Department of Medical Oncology, King Hussein Cancer Center, Amman, Jordan
  
• ISSN：1941-6636

文摘

Objective To present a comprehensive account and literature review addressing the anatomical distribution, natural history, and management strategies for locoregional recurrence in early-stage gastric cancer (EGC). Patients and methods Retrospective chart review of patients presenting with EGC recurrence at King Hussein Cancer Center (Amman, Jordan) between July 2006 and May 2009. A literature review of publications addressing recurrence following surgery for EGC was undertaken via a systematic search of PUBMED database and National Comprehensive Cancer Network (NCCN) guideline updates. Results Seventeen patients presented with EGC, three of whom (17.6%) were pathologically staged as T2N1 [1/33 lymph nodes (LNs)], T1N0, and T1N0 were afflicted by recurrence following R0 partial gastrectomy. Literature review yielded 18 studies specifically addressing recurrence in EGC. Several management strategies have been proposed for isolated recurrence following gastrectomy in EGC. NCCN clinical practice guideline updates do not take into consideration whether the recurrence is isolated or widespread and whether the initial stage is early or advanced. Conclusions While acknowledging the limitations of this study, including the small sample size and the short follow-up period, it appears clear that oncologic treatment is possible for EGC recurrence, particularly, in patients with isolated relapse. Guideline updates should differentiate between management strategies suitable for recurrence occurring in early versus advanced initial cancer stage.