Sexually dimorphic effects of early life stress in rat pups on urinary bladder detrusor muscle contractility in adulthood
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  • 作者:Ehsan Mohammadi ; Dawn K. Prusator ; Eleanor Healing…
  • 关键词:Painful bladder syndrome/interstitial cystitis ; Sex differences ; Early life stress ; Rats ; Urinary bladder ; Males ; Females
  • 刊名:Biology of Sex Differences
  • 出版年:2016
  • 出版时间:December 2016
  • 年:2016
  • 卷:7
  • 期:1
  • 全文大小:1,585 KB
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  • 作者单位:Ehsan Mohammadi (3)
    Dawn K. Prusator (3)
    Eleanor Healing (3)
    Robert Hurst (3) (4)
    Rheal A. Towner (3) (5)
    Amy B. Wisniewski (4)
    Beverley Greenwood-Van Meerveld (1) (2) (3)

    3. Oklahoma Center for Neuroscience, University of Oklahoma Health Science Center, Oklahoma City, OK, USA
    4. Department of Urology, University of Oklahoma Health Science Center, Oklahoma City, OK, USA
    5. Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    1. VA Medical Center, Oklahoma City, OK, USA
    2. Department of Physiology, University of Oklahoma Health Science Center, Oklahoma City, OK, USA
  • 刊物主题:Human Physiology; Endocrinology;
  • 出版者:BioMed Central
  • ISSN:2042-6410
文摘
Background Painful bladder syndrome/interstitial cystitis (PBS/IC) is a chronic disorder that is commonly seen in women who report a history of adversity in early life. Here, we test the hypothesis that early life stress (ELS) induces sexually dimorphic abnormalities in urinary bladder smooth muscle function in adulthood.

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