Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster
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- 作者：Lucie Kučerová ; Olga I. Kubrak ; Jonas M. Bengtsson ; Hynek Strnad…
- 刊名：BMC Genomics
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：17
- 期：1
- 全文大小：2,937 KB
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Olga I. Kubrak (2)
Jonas M. Bengtsson (2)
Hynek Strnad (3)
Sören Nylin (2)
Ulrich Theopold (1)
Dick R. Nässel (2)
1. Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm, Sweden
2. Department of Zoology, Stockholm University, S-106 91, Stockholm, Sweden
3. Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic - 刊物主题：Life Sciences, general; Microarrays; Proteomics; Animal Genetics and Genomics; Microbial Genetics and Genomics; Plant Genetics & Genomics;
- 出版者：BioMed Central
- ISSN：1471-2164
文摘
Background In models extensively used in studies of aging and extended lifespan, such as C. elegans and Drosophila, adult senescence is regulated by gene networks that are likely to be similar to ones that underlie lifespan extension during dormancy. These include the evolutionarily conserved insulin/IGF, TOR and germ line-signaling pathways. Dormancy, also known as dauer stage in the larval worm or adult diapause in the fly, is triggered by adverse environmental conditions, and results in drastically extended lifespan with negligible senescence. It is furthermore characterized by increased stress resistance and somatic maintenance, developmental arrest and reallocated energy resources. In the fly Drosophila melanogaster adult reproductive diapause is additionally manifested in arrested ovary development, improved immune defense and altered metabolism. However, the molecular mechanisms behind this adaptive lifespan extension are not well understood.