Design of Tissue Engineering Implants for Bone Tissue Regeneration of the Basis of New Generation Polylactoglycolide Scaffolds and Multipotent Mesenchymal Stem Cells from Human Exfoliated Deciduous Teeth (SHED Cells)

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• 作者：I. V. Vakhrushev (2) vakhrunya@gmail.com
  E. N. Antonov (13)
  A. V. Popova (13)
  E. V. Konstantinova (2)
  P. A. Karalkin (2)
  I. V. Kholodenko (12)
  A. Yu. Lupatov (2)
  V. K. Popov (13)
  V. N. Bagratashvili (13)
  K. N. Yarygin (2)
• 关键词：Key Words mesenchymal stem cells – ; dental pulp – ; biodegradable scaffold – ; selective laser sintering – ; tissue engineering
• 刊名：Bulletin of Experimental Biology and Medicine
• 出版年：2012
• 出版时间：May 2012
• 年：2012
• 卷：153
• 期：1
• 页码：143-147
• 全文大小：684.4 KB
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• 作者单位：1. Stemma Research-and-Production Complex, Moscow, Russia2. V. N. Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia3. Institute of Laser and Information Technologies, Russian Academy of Sciences, Moscow, Russia
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Biomedicine
  Internal Medicine
  Cell Biology
  Pathology
  Laboratory Medicine
  Russian Library of Science
  
• 出版者：Springer New York
• ISSN：1573-8221

文摘

Cultures of multipotent mesenchymal stromal cells from the pulp of human deciduous teeth (SHED cells) were characterized. The cells were used for population of 3D biodegradable polylactoglycolide scaffolds; their osteogenic potential was preserved under these conditions. Implantation of the scaffolds to mice induced no negative reactions in the recipients. These results suggest that the use of polylactoglycolide scaffolds populated with SHED cells is a promising approach for creation of implants for bone defect replacement.