Wnt activity guides facial branchiomotor neuron migration, and involves the PCP pathway and JNK and ROCK kinases
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- 作者：Valérie Vivancos (1)
Ping Chen (2)
Nathalie Spassky (3)
Dong Qian (2)
Alain Dabdoub (4)
Matthew Kelley (5)
Michèle Studer (6)
Sarah Guthrie (1) - 刊名：Neural Development
- 出版年：2009
- 出版时间：December 2009
- 年：2009
- 卷：4
- 期：1
- 全文大小：4007KB
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Ping Chen (2)
Nathalie Spassky (3)
Dong Qian (2)
Alain Dabdoub (4)
Matthew Kelley (5)
Michèle Studer (6)
Sarah Guthrie (1)
1. MRC Centre for Developmental Neurobiology, King's College, Guy's Campus, SE1 1UL, London, UK
2. Department of Cell Biology, Emory University School of Medicine, 615 Michael St, 30322, Atlanta, GA, USA
3. Biologie des Interactions Neurones/Glie, Unite Mixte de Recherche INSERM U-711 UPMC, H?pital de la Saltpetriere, Batiment de Pharmacie, cedex 13, 75651, Paris, France
4. Department of Surgery, Division of Otolaryngology, UCSD School of Medicine, Gilman Drive, 92093-0666, La Jolla, CA, USA
5. NIDCD/NIH, Porter Neuroscience Research Center, Convent Drive, 20892-3729, Bethesda, MD, USA
6. TIGEM, Via P Castellino 111, 80131, Naples, Italy
文摘
Background Wnt proteins play roles in many biological processes, including axon guidance and cell migration. In the mammalian hindbrain, facial branchiomotor (FBM) neurons undergo a striking rostral to caudal migration, yet little is known of the underlying molecular mechanisms. In this study, we investigated a possible role of Wnts and the planar cell polarity (PCP) pathway in this process. Results Here we demonstrate a novel role for Wnt proteins in guiding FBM neurons during their rostral to caudal migration in the hindbrain. We found that Wnt5a is expressed in a caudalhigh to rostrallow gradient in the hindbrain. Wnt-coated beads chemoattracted FBM neurons to ectopic positions in an explant migration assay. The rostrocaudal FBM migration was moderately perturbed in Wnt5a mutant embryos and severely disrupted in Frizzled3 mutant mouse embryos, and was aberrant following inhibition of Wnt function by secreted Frizzled-related proteins. We also show the involvement of the Wnt/PCP pathway in mammalian FBM neuron migration. Thus, mutations in two PCP genes, Vangl2 and Scribble, caused severe defects in FBM migration. Inhibition of JNK and ROCK kinases strongly and specifically reduced the FBM migration, as well as blocked the chemoattractant effects of ectopic Wnt proteins. Conclusion These results provide in vivo evidence that Wnts chemoattract mammalian FBM neurons and that Wnt5a is a candidate to mediate this process. Molecules of the PCP pathway and the JNK and ROCK kinases also play a role in the FBM migration and are likely mediators of Wnt signalling.