Relationship between deep subcutaneous abdominal adipose tissue and metabolic syndrome: a case control study

详细信息    查看全文

• 作者：Se-Hong Kim ; Ju-hye Chung ; Sang-Wook Song…
• 关键词：Superficial subcutaneous adipose tissue ; Deep subcutaneous adipose tissue ; Visceral adipose tissue ; Metabolic syndrome ; Inflammatory cytokine ; Adipocytokine
• 刊名：Diabetology and Metabolic Syndrome
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：8
• 期：1
• 全文大小：1,210 KB
• 参考文献：1.Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA. 2002;288:2709–16.CrossRef PubMed
  2.Carr DB, Utzschneider KM, Hull RL, Kodama K, Retzlaff BM, Brunzell JD, et al. Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome. Diabetes. 2004;53:2087–94.CrossRef PubMed
  3.Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2006;444:881–7.CrossRef PubMed
  4.Cancello R, Zulian A, Gentilini D, Maestrini S, Della Barba A, Invitti C, et al. Molecular and morphologic characterization of superficial- and deep-subcutaneous adipose tissue subdivisions in human obesity. Obesity (Silver Spring). 2013;21:2562–70.CrossRef
  5.Monzon JR, Basile R, Heneghan S, Udupi V, Green A. Lipolysis in adipocytes isolated from deep and superficial subcutaneous adipose tissue. Obes Res. 2002;10:266–9.CrossRef PubMed
  6.Walker GE, Verti B, Marzullo P, Savia G, Mencarelli M, Zurleni F, et al. Deep subcutaneous adipose tissue: a distinct abdominal adipose depot. Obesity (Silver Spring). 2007;15:1933–43.CrossRef
  7.Marinou K, Hodson L, Vasan SK, Fielding BA, Banerjee R, Brismar K, et al. Structural and functional properties of deep abdominal subcutaneous adipose tissue explain its association with insulin resistance and cardiovascular risk in men. Diabetes Care. 2014;37:821–9.CrossRef PubMed
  8.Kelley DE, Thaete FL, Troost F, Huwe T, Goodpaster BH. Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance. Am J Physiol Endocrinol Metab. 2000;278:E941–8.PubMed
  9.Smith SR, Lovejoy JC, Greenway F, Ryan D, deJonge L, de la Bretonne J, et al. Contributions of total body fat, abdominal subcutaneous adipose tissue compartments, and visceral adipose tissue to the metabolic complications of obesity. Metabolism. 2001;50:425–35.CrossRef PubMed
  10.Golan R, Shelef I, Rudich A, Gepner Y, Shemesh E, Chassidim Y, et al. Abdominal superficial subcutaneous fat: a putative distinct protective fat subdepot in type 2 diabetes. Diabetes Care. 2012;35:640–7.PubMedCentral CrossRef PubMed
  11.Deschenes D, Couture P, Dupont P, Tchernof A. Subdivision of the subcutaneous adipose tissue compartment and lipid-lipoprotein levels in women. Obes Res. 2003;11:469–76.CrossRef PubMed
  12.Walker GE, Marzullo P, Verti B, Guzzaloni G, Maestrini S, Zurleni F, et al. Subcutaneous abdominal adipose tissue subcompartments: potential role in rosiglitazone effects. Obesity (Silver Spring). 2008;16:1983–91.CrossRef
  13.Walker GE, Marzullo P, Ricotti R, Bona G, Prodam F. The pathophysiology of abdominal adipose tissue depots in health and disease. Horm Mol Biol Clin Investig. 2014;19:57–74.PubMed
  14.Mazaheri S, Sadeghi M, Sarrafzadegan N, Sanei H, Hekmatnia A, Tavakoli B. Correlation between body fat distribution, plasma lipids and apolipoproteins with the severity of coronary involvement in patients with stable angina. ARYA Atheroscler. 2011;6:140–3.PubMedCentral PubMed
  15.Nimitphong H, Phongkitkarun S, Rattarasarn C, Kongsooksai A, Chanprasertyothin S, Bunnag PA, et al. Hepatic fat content is a determinant of postprandial triglyceride levels in type 2 diabetes mellitus patients with normal fasting triglyceride. Metabolism. 2008;57:644–9.CrossRef PubMed
  16.Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005;112:2735–52.CrossRef PubMed
  17.Fujikawa R, Ito C, Nakashima R, Orita Y, Ohashi N. Is there any association between subcutaneous adipose tissue area and plasma total and high molecular weight adiponectin levels? Metabolism. 2008;57:506–10.CrossRef PubMed
  18.Goodpaster BH, Thaete FL, Simoneau JA, Kelley DE. Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes. 1997;46:1579–85.CrossRef PubMed
  19.Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, Liu CY, et al. Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation. 2007;116:39–48.CrossRef PubMed
  20.Tordjman J, Divoux A, Prifti E, Poitou C, Pelloux V, Hugol D, et al. Structural and inflammatory heterogeneity in subcutaneous adipose tissue: relation with liver histopathology in morbid obesity. J Hepatol. 2012;56:1152–8.CrossRef PubMed
  21.He H, Ni Y, Chen J, Zhao Z, Zhong J, Liu D, et al. Sex difference in cardiometabolic risk profile and adiponectin expression in subjects with visceral fat obesity. Transl Res. 2010;155:71–7.CrossRef PubMed
  22.Iglesias MJ, Eiras S, Pineiro R, Lopez-Otero D, Gallego R, Fernandez AL, et al. Gender differences in adiponectin and leptin expression in epicardial and subcutaneous adipose tissue. Findings in patients undergoing cardiac surgery. Rev Esp Cardiol. 2006;59:1252–60.CrossRef PubMed
  23.Lonnqvist F, Thorne A, Large V, Arner P. Sex differences in visceral fat lipolysis and metabolic complications of obesity. Arterioscler Thromb Vasc Biol. 1997;17:1472–80.CrossRef PubMed
  24.Fujita K, Nishizawa H, Funahashi T, Shimomura I, Shimabukuro M. Systemic oxidative stress is associated with visceral fat accumulation and the metabolic syndrome. Circ J. 2006;70:1437–42.CrossRef PubMed
  25.Lundbom J, Hakkarainen A, Lundbom N, Taskinen MR. Deep subcutaneous adipose tissue is more saturated than superficial subcutaneous adipose tissue. Int J Obes (Lond). 2013;37:620–2.CrossRef
  26.McLaughlin T, Sherman A, Tsao P, Gonzalez O, Yee G, Lamendola C, et al. Enhanced proportion of small adipose cells in insulin-resistant vs insulin-sensitive obese individuals implicates impaired adipogenesis. Diabetologia. 2007;50:1707–15.CrossRef PubMed
  27.Scaglione R, Di Chiara T, Cariello T, Licata G. Visceral obesity and metabolic syndrome: two faces of the same medal? Intern Emerg Med. 2010;5:111–9.CrossRef PubMed
  28.Yatagai T, Nagasaka S, Taniguchi A, Fukushima M, Nakamura T, Kuroe A, et al. Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus. Metabolism. 2003;52:1274–8.CrossRef PubMed
  29.Kwon K, Jung SH, Choi C, Park SH. Reciprocal association between visceral obesity and adiponectin: in healthy premenopausal women. Int J Cardiol. 2005;101:385–90.CrossRef PubMed
  30.Silha JV, Nyomba BL, Leslie WD, Murphy LJ. Ethnicity, insulin resistance, and inflammatory adipokines in women at high and low risk for vascular disease. Diabetes Care. 2007;30:286–91.CrossRef PubMed
  31.Walker GE, Marzullo P, Prodam F, Bona G, Di Blasio AM. Obesity modifies expression profiles of metabolic markers in superficial and deep subcutaneous abdominal adipose tissue depots. Endocrine. 2014;46:99–106.CrossRef PubMed
  32.Koistinen HA, Bastard JP, Dusserre E, Ebeling P, Zegari N, Andreelli F, et al. Subcutaneous adipose tissue expression of tumour necrosis factor-alpha is not associated with whole body insulin resistance in obese nondiabetic or in type-2 diabetic subjects. Eur J Clin Invest. 2000;30:302–10.CrossRef PubMed
  33.Lee JM, Kim SR, Yoo SJ, Hong OK, Son HS, Chang SA. The relationship between adipokines, metabolic parameters and insulin resistance in patients with metabolic syndrome and type 2 diabetes. J Int Med Res. 2009;37:1803–12.CrossRef PubMed
  34.Pou KM, Massaro JM, Hoffmann U, Vasan RS, Maurovich-Horvat P, Larson MG, et al. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Circulation. 2007;116:1234–41.CrossRef PubMed
  35.Njajou OT, Kanaya AM, Holvoet P, Connelly S, Strotmeyer ES, Harris TB, et al. Association between oxidized LDL, obesity and type 2 diabetes in a population-based cohort, the Health, Aging and Body Composition Study. Diabetes Metab Res Rev. 2009;25:733–9.PubMedCentral CrossRef PubMed
  36.Indulekha K, Anjana RM, Surendar J, Mohan V. Association of visceral and subcutaneous fat with glucose intolerance, insulin resistance, adipocytokines and inflammatory markers in Asian Indians (CURES-113). Clin Biochem. 2011;44:281–7.CrossRef PubMed
  37.Utzschneider KM, Carr DB, Tong J, Wallace TM, Hull RL, Zraika S, et al. Resistin is not associated with insulin sensitivity or the metabolic syndrome in humans. Diabetologia. 2005;48:2330–3.CrossRef PubMed
  38.Norata GD, Ongari M, Garlaschelli K, Raselli S, Grigore L, Catapano AL. Plasma resistin levels correlate with determinants of the metabolic syndrome. Eur J Endocrinol. 2007;156:279–84.CrossRef PubMed
  39.Reilly MP, Lehrke M, Wolfe ML, Rohatgi A, Lazar MA, Rader DJ. Resistin is an inflammatory marker of atherosclerosis in humans. Circulation. 2005;111:932–9.CrossRef PubMed
  40.Azuma K, Katsukawa F, Oguchi S, Murata M, Yamazaki H, Shimada A, et al. Correlation between serum resistin level and adiposity in obese individuals. Obes Res. 2003;11:997–1001.CrossRef PubMed
  
• 作者单位：Se-Hong Kim (1)
  Ju-hye Chung (2)
  Sang-Wook Song (1)
  Won Sang Jung (3)
  Yun-Ah Lee (1)
  Ha-Na Kim (1)
  
  1. Department of Family Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, 93-6 Ji-dong, Paldal-Gu, Suwon, Kyonggi-do, 442-723, Republic of Korea
  2. Department of Family Medicine, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 271, Cheon Bo-ro, Uijeongbu, Gyeonggi-do, 480-717, Republic of Korea
  3. Department of Radiology, College of Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, 93-6 Ji-dong, Paldal-Gu, Suwon, Kyonggi-do, 442-723, Republic of Korea
  
• 刊物主题：Diabetes; Metabolic Diseases; Endocrinology;
• 出版者：BioMed Central
• ISSN：1758-5996

文摘

Background The deep subcutaneous adipose tissue (dSAT) is closely related to the obesity-associated complications similarly to the characteristics of visceral adipose tissue (VAT). However, the association between dSAT and metabolic syndrome (MS) is unclear. The purpose of our study was to evaluate the association of distinct abdominal adipose tissue with the cardiometabolic risk factors and MS.