Schleimhautbeteiligung bei blasenbildenden Autoimmunerkrankungen

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• 作者：PD Dr. C. Günther
• 关键词：SchlüsselwörterPemphigus vulgaris ; Schleimhautpemphigoid ; Autoantikörper ; Immunsuppression ; Systemische Therapie
• 刊名：Der Hautarzt
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：67
• 期：10
• 页码：774-779
• 全文大小：565 KB
• 刊物主题：Dermatology; Immunology; Allergology; Proctology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-1173
• 卷排序：67

文摘

Autoimmune bullous diseases are characterized by intraepidermal or subepidermal autoantibody deposition that leads to blisters and secondary erosion. Mucous membranes are frequently affected in pemphigus vulgaris and always involved in cicatricial and mucosal pemphigoid. Mucosal lesions are detected less frequently in patients with bullous pemphigoid or epidermolysis bullosa acquisita. The diagnosis of autoimmune bullous disorders is based on determination of the subtype of autoantibodies bound in the skin and the clinical picture. Treatment is based on immunosuppression related to the type of disease and severity of the mucosal symptoms. Ocular involvement in mucosal pemphigoid and pemphigus vulgaris requires systemic treatment.