Ultrastructural markers of quality are impaired in human metaphase II aged oocytes: a comparison between reproductive and in vitro aging

详细信息    查看全文

• 作者：S. Bianchi ; G. Macchiarelli ; G. Micara…
• 关键词：Oocyte ; Aging ; Quality ; Assisted reproduction ; Human ; Ultrastructure
• 刊名：Journal of Assisted Reproduction and Genetics
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：32
• 期：9
• 页码：1343-1358
• 全文大小：4,921 KB
• 参考文献：1.Broekmans FJ, Soules MR, Fauser BC. Ovarian aging: mechanisms and clinical consequences. Endocr Rev. 2009;30:465鈥?3.CrossRef PubMed
  2.Kocourkova J, Burcin B, Kucera T. Demographic relevancy of increased use of assisted reproduction in European countries. Reprod Health. 2014;26:11鈥?7.
  3.Miao YL, Kikuchi K, Sun QY, Schatten H. Oocyte aging: cellular and molecular changes, developmental potential and reversal possibility. Hum Reprod Update. 2009;15:573鈥?5.CrossRef PubMed
  4.Leridon H. Can assisted reproduction technology compensate for the natural decline in fertility with age? A model assessment. Hum Reprod. 2004;19:1548鈥?3.CrossRef PubMed
  5.Bentov Y, Yavorska T, Esfandiari N, Jurisicova A, Casper RF. The contribution of mitochondrial function to reproductive aging. J Assist Reprod Genet. 2011;28:773鈥?3.PubMed Central CrossRef PubMed
  6.Qiao J, Wang ZB, Feng HL, Miao YL, Wang Q, Yu Y, et al. The root of reduced fertility in aged women and possible therapeutic options: current status and future prospects. Mol Aspects Med. 2013;38:54鈥?5.CrossRef PubMed
  7.Navot D, Bergh PA, Williams MA, Garrisi GJ, Guzman I, Sandler B, et al. Poor oocyte quality rather than implantation failure as a cause of age-related decline in female fertility. Lancet. 1991;337:1375鈥?.CrossRef PubMed
  8.Battaglia DE, Goodwin P, Klein NA, Soules MR. Influence of maternal age on meiotic spindle assembly in oocytes from naturally cycling women. Hum Reprod. 1996;11:2217鈥?2.CrossRef PubMed
  9.de Bruin JP, Dorland M, Spek ER, Posthuma G, van Haaften M, Looman CW, et al. Age-related changes in the ultrastructure of the resting follicle pool in human ovaries. Biol Reprod. 2004;70:419鈥?4.CrossRef PubMed
  10.Wilcox AJ, Weinberg CR, Baird DD. Post-ovulatory aging of the human oocyte and embryo failure. Hum Reprod. 1998;13:394鈥?.CrossRef PubMed
  11.Chen C, Kattera S. Rescue ICSI of oocytes that failed to extrude the second polar body 6 h post-insemination in conventional IVF. Hum Reprod. 2003;18:2118鈥?1.CrossRef PubMed
  12.Van Blerkom J. Mitochondrial function in the human oocyte and embryo and their role in developmental competence. Mitochondrion. 2011;11:797鈥?13.CrossRef PubMed
  13.Nasr-Esfahani MH, Deemeh MR, Tavalaee M. Artificial oocyte activation and intracytoplasmic sperm injection. Fertil Steril. 2010;94:520鈥?.CrossRef PubMed
  14.Beck-Fruchter R, Lavee M, Weiss A, Geslevich Y, Shalev E. Rescue intracytoplasmic sperm injection: a systematic review. Fertil Steril. 2014;101:690鈥?.CrossRef PubMed
  15.Coticchio G. Polarization microscopy and rescue ICSI. Reprod Biomed Online. 2013;26:222鈥?.CrossRef PubMed
  16.Stensen MH, Tanbo T, Storeng R, Byholm T, F猫dorcsak P. Routine morphological scoring systems in assisted reproduction treatment fail to reflect age-related impairment of oocyte and embryo quality. Reprod Biomed Online. 2010;21:118鈥?5.CrossRef PubMed
  17.Khalili MA, Maione M, Palmerini MG, Bianchi S, Macchiarelli G, Nottola SA. Ultrastructure of human mature oocytes after vitrification. Eur J Histochem. 2012;56:e38.PubMed Central CrossRef PubMed
  18.Nottola SA, Macchiarelli G, Coticchio G, Bianchi S, Cecconi S, De Santis L, et al. Ultrastructure of human mature oocytes after slow cooling cryopreservation using different sucrose concentrations. Hum Reprod. 2007;22:1123鈥?3.CrossRef PubMed
  19.Nottola SA, Coticchio G, De Santis L, Macchiarelli G, Maione M, Bianchi S, et al. Ultrastructure of human mature oocytes after slow cooling cryopreservation with ethylene glycol. Reprod Biomed Online. 2008;17:368鈥?7.CrossRef PubMed
  20.Nottola SA, Coticchio G, Sciajno R, Gambardella A, Maione M, Scaravelli G, et al. Ultrastructural markers of quality in human mature oocytes vitrified using cryoleaf and cryoloop. Reprod Biomed Online. 2009;19:17鈥?7.CrossRef PubMed
  21.Coticchio G, De Santis L, Rossi G, Borini A, Albertini D, Scaravelli G, et al. Sucrose concentration influences the rate of human oocytes with normal spindle and chromosome configurations after slow-cooling cryopreservation. Hum Reprod. 2006;21:1771鈥?.CrossRef PubMed
  22.Coticchio G, Borini A, Distratis V, Maione M, Scaravelli G, Bianchi V, et al. Qualitative and morphometric analysis of the ultrastructure of human oocytes cryopreserved by two alternative slow cooling protocols. J Assist Reprod Genet. 2010;27:131鈥?0.PubMed Central CrossRef PubMed
  23.Shahedi A, Hosseini A, Khalili MA, Norouzian M, Salehi M, Piriaei A, et al. The effect of vitrification on ultrastructure of human in vitro matured germinal vesicle oocytes. Eur J Obstet Gynecol Reprod Biol. 2013;167:69鈥?5.CrossRef PubMed
  24.Palmerini MG, Antinori M, Maione M, Cerusico F, Versaci C, Nottola SA, et al. Ultrastructure of immature and mature human oocytes after cryotop vitrification. J Reprod Dev. 2014;60:411鈥?0.PubMed Central CrossRef PubMed
  25.Coticchio G, Sciajno R, Hutt K, Bromfield J, Borini A, Albertini DF. Comparative analysis of the metaphase II spindle of human oocytes through polarized light and high-performance confocal microscopy. Fertil Steril. 2010;93:2056鈥?4.CrossRef PubMed
  26.Sundstrom P, Nilsson BO, Liedholm P, Larsson E. Ultrastructural characteristics of human oocytes fixed at follicular puncture or after culture. J In Vitro Fert Embryo Transf. 1985;2:195鈥?06.CrossRef PubMed
  27.Sathananthan AH. Ultrastructure of the human egg. Hum Cell. 1997;10:21鈥?8.PubMed
  28.Volarcik K, Sheean L, Goldfarb J, Woods L, Abdul-Karim FW, Hunt P. The meiotic competence of in-vitro matured human oocytes is influenced by donor age: evidence that folliculogenesis is compromised in the reproductively aged ovary. Hum Reprod. 1998;13:154鈥?0.CrossRef PubMed
  29.George MA, Pickering SJ, Braude PR, Johnson MH. The distribution of alpha- and gamma-tubulin in fresh and aged human and mouse oocytes exposed to cryoprotectant. Mol Hum Reprod. 1996;2:445鈥?6.CrossRef PubMed
  30.Rienzi L, Balaban B, Ebner T, Mandelbaum J. The oocyte. Hum Reprod. 2012;27:i2鈥?1.CrossRef PubMed
  31.Lin YH, Hwang JL, Huang LW, Seow KM, Hsieh BC, Tzeng CR. Comparison of Quinn鈥檚 Advantage fertilization medium and tissue culture medium 199 for in vitro maturation of oocytes. Taiwan J Obstet Gynecol. 2014;53:17鈥?0.CrossRef PubMed
  32.Shih YF, Lee TH, Liu CH, Tsao HM, Huang CC, Lee MS. Effects of reactive oxygen species levels in prepared culture media on embryo development: a comparison of two media. Taiwan J Obstet Gynecol. 2014;53:504鈥?.CrossRef PubMed
  33.Motta PM, Nottola SA, Micara G, Familiari G. Ultrastructure of human unfertilized oocytes and polyspermic embryos in an IVF-ET program. Ann N Y Acad Sci. 1988;541:367鈥?3.CrossRef PubMed
  34.Gualtieri R, Iaccarino M, Mollo V, Prisco M, Iaccarino S, Talevi R. Slow cooling of human oocytes: ultrastructural injuries and apoptotic status. Fertil Steril. 2009;91:1023鈥?4.CrossRef PubMed
  35.El Shafie M, Sousa M, Windt M-L, Kruger TF. An atlas of the ultrastructure of human oocytes. New York, USA: Parthenon; 2000.
  36.Bianchi V, Macchiarelli G, Borini A, Lappi M, Cecconi S, Miglietta S, et al. Fine morphological assessment of quality of human mature oocytes after slow freezing or vitrification with a closed device: a comparative analysis. Reprod Biol Endocrinol. 2014;12:110.PubMed Central CrossRef PubMed
  37.S谩 R, Cunha M, Silva J, Lu铆s A, Oliveira C, Teixeira da Silva J, et al. Ultrastructure of tubular smooth endoplasmic reticulum aggregates in human metaphase II oocytes and clinical implications. Fertil Steril. 2011;96:143鈥?9.CrossRef PubMed
  38.Ebner T, Moser M, Shebl O, Sommerguber M, Tews G. Prognosis of oocytes showing aggregation of smooth endoplasmic reticulum. Reprod Biomed Online. 2008;16:113鈥?.CrossRef PubMed
  39.Otsuki J, Okada A, Morimoto K, Nagai Y, Kubo H. The relationship between pregnancy outcome and smooth endoplasmic reticulum clusters in MII human oocytes. Hum Reprod. 2004;19:1591鈥?.CrossRef PubMed
  40.Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology. The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum Reprod. 2011;26:1270鈥?3.CrossRef
  41.Mateizel I, Van Landuyt L, Tournaye H, Verheyen G. Deliveries of normal healthy babies from embryos originating from oocytes showing the presence of smooth endoplasmic reticulum aggregates. Hum Reprod. 2013;28:2111鈥?.CrossRef PubMed
  42.Motta PM, Nottola SA, Makabe S, Heyn R. Mitochondrial morphology in human fetal and adult female germ cells. Hum Reprod. 2000;15:129鈥?7.CrossRef PubMed
  43.Motta PM, Nottola SA, Familiari G, Makabe S, Stallone T, Macchiarelli G. Morphodynamics of the follicular-luteal complex during early ovarian development and reproductive life. Int Rev Cytol. 2003;223:177鈥?88.CrossRef PubMed
  44.Van Blerkom J, Davis P, Mathwig V, Alexander S. Domains of high-polarized and low-polarized mitochondria may occur in mouse and human oocytes and early embryos. Hum Reprod. 2002;17:393鈥?06.CrossRef PubMed
  45.Van Blerkom J, Davis P. Mitochondrial signaling and fertilization. Mol Hum Reprod. 2007;13:759鈥?0.CrossRef PubMed
  46.Sousa M, Barros A, Silva J, Tesarik J. Developmental changes in calcium content of ultrastructurally distinct subcellular compartments of preimplantation human embryos. Mol Hum Reprod. 1997;3:83鈥?0.CrossRef PubMed
  47.Swann K, Ozil JP. Dynamics of the calcium signal that triggers mammalian egg activation. Int Rev Cytol. 1994;152:183鈥?22.CrossRef PubMed
  48.Nikiforaki D, Vanden Meerschaut F, Qian C, De Croo I, Lu Y, Deroo T, et al. Oocyte cryopreservation and in vitro culture affect calcium signalling during human fertilization. Hum Reprod. 2014;29:29鈥?0.CrossRef PubMed
  49.Stricker SA. Structural reorganizations of the endoplasmic reticulum during egg maturation and fertilization. Semin Cell Dev Biol. 2006;17:303鈥?3.CrossRef PubMed
  50.Ghadially FN. Ultrastructural pathology of the cell and matrix. 4th ed. Boston, USA: Butterworth-Heinemann; 1997.
  51.McGinnis LK, Pelech S, Kinsey WH. Post-ovulatory aging of oocytes disrupts kinase signaling pathways and lysosome biogenesis. Mol Reprod Dev. 2014;81:928鈥?5.PubMed Central CrossRef PubMed
  52.Muller-Hocker J, Schafer S, Weis S, Munscher C, Strowitzki T. Morphological-cytochemical and molecular genetic analysis of mitochondria in isolated human oocytes in the reproductive age. Mol Hum Reprod. 1996;2:951鈥?.CrossRef PubMed
  53.Van Blerkom J, Davis P, Lee J. ATP content of human oocytes and developmental potential and outcome after in-vitro fertilization and embryo transfer. Hum Reprod. 1995;10:415鈥?4.PubMed
  54.Sathananthan AH. Ultrastructure of human gametes, fertilization and embryos in assisted reproduction: a personal survey. Micron. 2013;44:1鈥?0.CrossRef PubMed
  55.Familiari G, Heyn R, Relucenti M, Nottola SA, Sathananthan AH. Ultrastructural dynamics of human reproduction, from ovulation to fertilization and early embryo development. Int Rev Cytol. 2006;249:53鈥?41.CrossRef PubMed
  56.Abbott AL, Xu Z, Kopf GS, Ducibella T, Schultz RM. In vitro culture retards spontaneous activation of cell cycle progression and cortical granule exocytosis that normally occur in in vivo unfertilized mouse eggs. Biol Reprod. 1998;59:1515鈥?1.CrossRef PubMed
  57.Tar铆n JJ, P茅rez-Albal谩 S, Cano A. Cellular and morphological traits of oocytes retrieved from aging mice after exogenous ovarian stimulation. Biol Reprod. 2001;65:141鈥?0.CrossRef PubMed
  58.D铆az H, Esponda P. Aging-induced changes in the cortical granules of mouse eggs. Zygote. 2004;12:95鈥?03.CrossRef PubMed
  59.Ducibella T, Duffy P, Reindollar R, Su B. Changes in the distribution of mouse oocyte cortical granules and ability to undergo the cortical reaction during gonadotropin-stimulated meiotic maturation and aging in vivo. Biol Reprod. 1990;43:870鈥?.CrossRef PubMed
  60.Sathananthan AH, Trounson AO. Ultrastructural observations on cortical granules in human follicular oocytes cultured in vitro. Gamete Res. 1982;5:191鈥?.CrossRef
  61.Ducibella T, Dubey A, Gross V, Emmi A, Penzias AS, Layman L, et al. A zona biochemical change and spontaneous cortical granule loss in eggs that fail to fertilize in in vitro fertilization. Fertil Steril. 1995;64:1154鈥?1.PubMed
  62.Talevi R, Gualtieri R, Tartaglione G, Fortunato A. Heterogeneity of the zona pellucida carbohydrate distribution in human oocytes failing to fertilize in vitro. Hum Reprod. 1997;12:2773鈥?0.CrossRef PubMed
  63.Manna C, Rienzi L, Greco E, Sbracia M, Rahman A, Poverini R, et al. Zona pellucida solubility and cortical granule complements in human oocytes following assisted reproductive techniques. Zygote. 2001;9:201鈥?0.CrossRef PubMed
  64.Familiari G, Nottola SA, Macchiarelli G, Micara G, Aragona C, Motta PM. Human zona pellucida during in vitro fertilization: an ultrastructural study using saponin, ruthenium red, and osmium-thiocarbohydrazide. Mol Reprod Dev. 1992;32:51鈥?1.CrossRef PubMed
  65.Pickering SJ, Johnson MH, Braude PR, Houliston E. Cytoskeletal organization in fresh, aged and spontaneously activated human oocytes. Hum Reprod. 1988;3:978鈥?9.PubMed
  66.Kim NH, Chung HM, Cha KY, Chung KS. Microtubule and microfilament organization in maturing human oocytes. Hum Reprod. 1998;13:2217鈥?2.CrossRef PubMed
  67.Coticchio G, Guglielmo MC, Albertini DF, Dal Canto M, Mignini Renzini M, De Ponti E, et al. Contributions of the actin cytoskeleton to the emergence of polarity during maturation in human oocytes. Mol Hum Reprod. 2014;20:200鈥?.CrossRef PubMed
  68.Sun QY, Schatten H. Regulation of dynamic events by microfilaments during oocyte maturation and fertilization. Reproduction. 2006;131:193鈥?05.CrossRef PubMed
  69.Runge KE, Evans JE, He ZY, Gupta S, McDonald KL, Stahlberg H, et al. Oocyte CD9 is enriched on the microvillar membrane and required for normal microvillar shape and distribution. Dev Biol. 2007;304:317鈥?5.CrossRef PubMed
  70.Sengoku K, Tamate K, Horikawa M, Takaoka Y, Ishikawa M, Dukelow WR. Plasma membrane block to polyspermy in human oocytes and preimplantation embryos. J Reprod Fertil. 1995;105:85鈥?0.CrossRef PubMed
  71.Park KS, Song HB, Chun SS. Late fertilization of unfertilized human oocytes in in vitro fertilization and intracytoplasmic sperm injection cycles: conventional insemination versus ICSI. J Assist Reprod Genet. 2000;17:419鈥?4.PubMed Central CrossRef PubMed
  72.Malter H, Talansky B, Gordon J, Cohen J. Monospermy and polyspermy after partial zona dissection of reinseminated human oocytes. Gamete Res. 1989;23:377鈥?6.CrossRef PubMed
  73.Nottola SA, Makabe S, Stallone T, Familiari G, Correr S, Macchiarelli G. Surface morphology of the zona pellucida surrounding human blastocysts obtained after in vitro fertilization. Arch Histol Cytol. 2005;68:133鈥?1.CrossRef PubMed
  74.Nawroth F, Muller P, Wolf C, Sudik R. Is the zona pellucida thickness of metaphase-II oocytes in an IVF/ICSI program influenced by the patient鈥檚 age? Gynecol Obstet Invest. 2001;52:55鈥?.CrossRef PubMed
  75.Kilani SS, Cooke S, Kan AK, Chapman MG. Do age and extended culture affect the architecture of the zona pellucida of human oocytes and embryos? Zygote. 2006;14:39鈥?4.CrossRef PubMed
  76.Valeri C, Pappalardo S, De Felici M, Manna C. Correlation of oocyte morphometry parameters with woman鈥檚 age. J Assist Reprod Genet. 2011;28:545鈥?2.PubMed Central CrossRef PubMed
  77.Nottola SA, Familiari G, Micara G, Aragona C, Motta PM. The ultrastructure of human cumulus-corona cells at the time of fertilization and early embryogenesis. A scanning and transmission electron microscopic study in an in vitro fertilization program. Arch Histol Cytol. 1991;54:145鈥?1.CrossRef PubMed
  78.Motta PM, Nottola SA, Pereda J, Croxatto HB, Familiari G. Ultrastructure of human cumulus oophorus: a transmission electron microscopic study on oviductal oocytes and fertilized eggs. Hum Reprod. 1995;10:2361鈥?.CrossRef PubMed
  79.Motta PM, Nottola SA, Familiari G, Macchiarelli G, Correr S, Makabe S. Structure and function of the human oocyte-cumulus-corona cell complex before and after ovulation. Protoplasma. 1999;206:270鈥?.CrossRef
  80.McReynolds S, Dzieciatkowska M, McCallie BR, Mitchell SD, Stevens J, Hansen K, et al. Impact of maternal aging on the molecular signature of human cumulus cells. Fertil Steril. 2012;98:1574鈥?0.CrossRef PubMed
  81.Bomsel-Helmreich O, Huyen LV, Durand-Gasselin I, Salat-Baroux J, Antoine JM. Mature and immature oocytes in large and medium follicles after clomiphene citrate and human menopausal gonadotropin stimulation without human chorionic gonadotropin. Fertil Steril. 1987;48:596鈥?04.PubMed
  82.Salhab M, Papillier P, Perreau C, Guyader-Joly C, Dupont J, Mermillod P, et al. Thymosins 尾-4 and 尾-10 are expressed in bovine ovarian follicles and upregulated in cumulus cells during meiotic maturation. Reprod Fertil Dev. 2010;22:1206鈥?1.CrossRef PubMed
  83.Hassold T, Hunt P. To err (meiotically) is human: the genesis of human aneuploidy. Nat Rev Genet. 2001;2:280鈥?1.CrossRef PubMed
  84.Eichenlaub-Ritter U, Stahl A, Luciani JM. The microtubular cytoskeleton and chromosomes of unfertilized human oocytes aged in vitro. Hum Genet. 1988;80:259鈥?4.CrossRef PubMed
  85.Miyara F, Aubriot FX, Glissant A, Nathan C, Douard S, Stanovici A, et al. Multiparameter analysis of human oocytes at metaphase II stage after IVF failure in non-male infertility. Hum Reprod. 2003;18:1494鈥?03.CrossRef PubMed
  86.Tsutsumi M, Fujiwara R, Nishizawa H, Ito M, Kogo H, Inagaki H, et al. Age-related decrease of meiotic cohesins in human oocytes. PLoS ONE. 2014;9:e96710.PubMed Central CrossRef PubMed
  87.Schatten H, Sun QY. Centrosome and microtubule functions and dysfunctions in meiosis: implications for age-related infertility and developmental disorders. Reprod Fertil Dev. 2015. doi:10.鈥?071/鈥婻D14493 .PubMed
  
• 作者单位：S. Bianchi (1)
  G. Macchiarelli (1)
  G. Micara (2)
  A. Linari (2)
  C. Boninsegna (2)
  C. Aragona (2)
  G. Rossi (1)
  S. Cecconi (1)
  S. A. Nottola (3)
  
  1. Department of Life, Health and Environmental Sciences, University of L鈥橝quila, L鈥橝quila, Italy
  2. Department of Gynaecology-Obstetrics & Urology, 鈥淪apienza鈥?University, Rome, Italy
  3. Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, 鈥淪apienza鈥?University, Rome, Italy
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gynecology
  Developmental Biology
  Human Genetics
  
• 出版者：Springer Netherlands
• ISSN：1573-7330

文摘

Purpose Childbearing delay contributes to the increase of subfertile couples that require assisted reproductive technology (ART). Subfertility relates with reproductive aging (RA). In vitro aging (IvA) (due to extended culture) may also impair oocyte competence. Aims of this study were to evaluate and compare the oocyte ultrastructure after RA and IvA.