The effect of father’s age in fertile, subfertile, and assisted reproductive technology pregnancies: A population based cohort study

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• 作者：Judy E. Stern (1)
  Barbara Luke (2)
  Mark D. Hornstein (3)
  Howard Cabral (4)
  Daksha Gopal (5)
  Hafsatou Diop (6)
  Milton Kotelchuck (7)
  
• 关键词：Paternal age ; Maternal age ; Subfertility ; ART ; IVF ; Preterm delivery ; Birthweight
• 刊名：Journal of Assisted Reproduction and Genetics
• 出版年：2014
• 出版时间：November 2014
• 年：2014
• 卷：31
• 期：11
• 页码：1437-1444
• 全文大小：176 KB
• 参考文献：1. Nangia AK, Luke B, Smith JF, Mak W, Stern JE, Group SW. National study of factors influencing assisted reproductive technology outcomes with male factor infertility. Fertil Steril. 2011;96:609-4. CrossRef
  2. Martin JA, Hamilton BE, Ventura S,J., Osterman M,JK, Wilson E,C., Mathews T. Births: Final Data for 2010. National Vital Statistics Reports 2012;61:1-2.
  3. Johnson J, Tough S. Society of O, Gynaecologists of C Delayed child-bearing. J Obstet Gynaecol Can. 2012;34:80-3.
  4. Luke B, Brown MB. Elevated risks of pregnancy complications and adverse outcomes with increasing maternal age. Hum Reprod. 2007;22:1264-2. CrossRef
  5. Reefhuis J, Honein MA. Maternal age and non-chromosomal birth defects, Atlanta-968-000: teenager or thirty-something, who is at risk? Birth Defects. Res Part A Clin Mol Teratol. 2004;70:572-. CrossRef
  6. Committee REaI, Liu K, Case A. Advanced Reproductive Age and Fertility: Clinical Practice Guideline. Journal of Obstetrics & Gynaecology Canada: JOGC 2011;269:1165-175.
  7. Sandin S, Hultman CM, Kolevzon A, Gross R, MacCabe JH, Reichenberg A. Advancing maternal age is associated with increasing risk for autism: a review and meta-analysis. J Am Acad Child Adolesc Psychiatry 2012;51:477-86.e1.
  8. De La Rochebrochard E, Thonneau P. Paternal age: are the risks of infecundity and miscarriage higher when the man is aged 40?years or over? Rev Epidemiol Sante Publique 2005;53 Spec No 2:2S47-55.
  9. Bellver J, Garrido N, Remohi J, Pellicer A, Meseguer M. Influence of paternal age on assisted reproduction outcome. Reprod Biomed Online. 2008;17:595-04. CrossRef
  10. Dain L, Auslander R, Dirnfeld M. The effect of paternal age on assisted reproduction outcome. Fertil Steril. 2011;95:1-. CrossRef
  11. Reichenberg A, Gross R, Weiser M, Bresnahan M, Silverman J, Harlap S, et al. Advancing paternal age and autism. Arch Gen Psychiatry. 2006;63:1026-2. CrossRef
  12. Yang Q, Wen SW, Leader A, Chen XK, Lipson J, Walker M. Paternal age and birth defects: how strong is the association? Hum Reprod. 2007;22:696-01. CrossRef
  13. Green RF, Devine O, Crider KS, Olney RS, Archer N, Olshan AF, et al. Association of paternal age and risk for major congenital anomalies from the National Birth Defects Prevention Study, 1997 to 2004. Ann Epidemiol. 2010;20:241-. CrossRef
  14. Grewal J, Carmichael SL, Yang W, Shaw GM. Paternal age and congenital malformations in offspring in California, 1989-002. Maternal & Child Health Journal. 2012;16:385-2. CrossRef
  15. Fonseka KGL, Griffin DK. Is there a paternal age effect for aneuploidy? Cytogenetic & Genome Research. 2011;133:280-1. CrossRef
  16. Kotelchuck M, Hoang L, Stern JE, Diop H, Belanoff C, Declercq E. The MOSART database: Linking the SART CORS clinical database to the population-based Massachusetts PELL reproductive public health data system. Maternal and Child Health Journal 2014;In Press.
  17. Declercq E, Belanoff C, Diop H, Gopal D, Hornstein MD, Kotelchuck M, et al. Identifying women with indicators of subfertility in a statewide population database: Operationalizing the missing link in ART research. Fertility & Sterility 2014;101:463-463-71.
  18. Oken E, Kleinman KP, Rich-Edwards J, Gillman MW. A nearly continuous measure of birth weight for gestational age using a United States national reference. BMC Pediatr. 2003;3:6. CrossRef
  19. Land JA. How should we report on perinatal outcome? Hum Reprod. 2006;21:2638-. CrossRef
  20. Practice
• 作者单位：Judy E. Stern (1)
  Barbara Luke (2)
  Mark D. Hornstein (3)
  Howard Cabral (4)
  Daksha Gopal (5)
  Hafsatou Diop (6)
  Milton Kotelchuck (7)
  
  1. Department of Obstetrics & Gynecology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA
  2. Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, East Lansing, MI, USA
  3. Department of Obstetrics and Gynecology Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, USA
  4. Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
  5. Boston University School of Public Health, Boston, MA, USA
  6. Massachusetts Department of Public Health, Boston, MA, USA
  7. MassGeneral Hospital for Children, Harvard Medical School, Boston, MA, USA
  
• ISSN：1573-7330

文摘

Purpose To compare ages of mothers and of fathers at delivery in couples who are fertile, subfertile, and subfertile treated with assisted reproductive technology (ART) and to characterize birth outcomes in the ART population according to paternal age. Methods Live birth deliveries in Massachusetts between July, 2004 and December, 2008 were identified from vital records and categorized by maternal fertility status and treatment as ART, subfertile or fertile. The ART births were linked to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) database to obtain cycle-specific treatment data. Parental ages were obtained from birth certificates. Age of mothers and fathers were compared using ANOVA for continuous measures and χ 2 for categories. Risks of prematurity ( Results The study population included 9,092 ART, 6,238 subfertile, and 318,816 fertile deliveries. Paternal ages in the ART and subfertile groups were similar and differed significantly from those of the fertile group. Maternal age in the ART and subfertile groups averaged 5-?years older than their fertile counterparts and fathers averaged 4-?years older with twice as many being older than 37. The risks for prematurity, low birthweight and SGA did not increase with increasing paternal age. Conclusions Fathers in ART- treated and subfertile couples are older than in their fertile counterparts. Older paternal age was not assoicated with increased risk for prematurity, low birthweight, or SGA.