Hormone-Based Treatments in Subfertile Males

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• 作者：Darshan P. Patel ; Jason C. Chandrapal ; James M. Hotaling
• 刊名：Current Urology Reports
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：17
• 期：8
• 全文大小：312 KB
• 刊物主题：Urology/Andrology; Nephrology;
• 出版者：Springer US
• ISSN：1534-6285
• 卷排序：17

文摘

Subfertility is defined as the condition of being less than normally fertile though still capable of effecting fertilization. When these subfertile couples seek assistance for conception, a thorough evaluation of male endocrine function is often overlooked. Spermatogenesis is a complex process where even subtle alterations in this process can lead to subfertility or infertility. Male endocrine abnormalities may suggest a specific diagnosis contributing to subfertility; however, in many patients, the underlying etiology is still unknown. Optimizing underlying endocrine abnormalities may improve spermatogenesis and fertility. This manuscript reviews reproductive endocrine abnormalities and hormone-based treatments.KeywordsMale infertilityHormone-based therapiesAzoospermiaClomiphene citrateAromatase inhibitorsHuman chorionic gonadotropin