Phlegmonous colitis: another source of sepsis in cirrhotic patients?

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• 作者：Thomas Holzer (1)
  Pascal Gervaz (1)
  Laurent Spahr (2)
  Thomas McKee (3)
  Pascal Bucher (1)
  Philippe Morel (1)
  
• 刊名：BMC Gastroenterology
• 出版年：2009
• 出版时间：December 2009
• 年：2009
• 卷：9
• 期：1
• 全文大小：1279KB
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  10. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-230X/9/94/prepub
  
• 作者单位：Thomas Holzer (1)
  Pascal Gervaz (1)
  Laurent Spahr (2)
  Thomas McKee (3)
  Pascal Bucher (1)
  Philippe Morel (1)
  
  1. Department of Surgery, Geneva University Hospital and Medical School, 4 rue Gabrielle-Perret-Gentil, 1211, Geneva, Switzerland
  2. Department of Gastroenterology, Geneva University Hospital and Medical School, 4 rue Gabrielle-Perret-Gentil, 1211, Geneva, Switzerland
  3. Department of Pathology, Geneva University Hospital and Medical School, 1 rue Michel-Servet, 1211, Geneva, Switzerland
  

文摘

Background The clinical relevance of phlegmonous colitis (PC), a rare autopsy finding in cirrhotic patients, is poorly documented. We postulated that PC might be a source of sepsis in patients with portal hypertensive colopathy (PHC). Case presentation We report three cirrhotic patients who were admitted with abdominal sepsis and who illustrate, to various degrees, the clinico-pathological sequence of colonic alterations associated with portal hypertension. Two cirrhotic patients with PHC developed gram-negative bacteraemia and quickly responded to intravenous antibiotics. Another cirrhotic patient underwent emergency colectomy for PC, and subsequently died from multiple organ failure. Histological alterations in the operative specimen included: a) mucosal ulcerations; b) disseminated micro-abscesses in the submucosa; and c) a severe vasculopathy leading to complete obliteration of submucosal blood vessels. Conclusions These data suggest that cirrhotic patients with PHC may progress towards PC, which, in turn, may be the cause for life-threatening sepsis.