Imaging of autoimmune hepatitis and overlap syndromes

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• 作者：Neera Malik ; Sudhakar K. Venkatesh
• 关键词：Autoimmune hepatitis ; Cirrhosis ; Primary sclerosing cholangitis ; Primary biliary cirrhosis ; MR elastography
• 刊名：Abdominal Radiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：42
• 期：1
• 页码：19-27
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Imaging / Radiology; Gastroenterology; Hepatology;
• 出版者：Springer US
• ISSN：2366-0058
• 卷排序：42

文摘

Autoimmune hepatitis (AIH) is an uncommon, chronic inflammatory, and relapsing liver disease of unknown origin that may lead to liver cirrhosis, hepatocellular carcinoma, liver transplantation, or death. AIH occurs in all age groups and races but can frequently manifest as acute fulminant hepatitis. Clinical presentation of AIH can have features similar to primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC), and these diseases may coexist leading to overlap syndromes. Although histological diagnosis is necessary, imaging features often can demonstrate characteristics that may be helpful to distinguish these diseases. Imaging features of AIH are those of chronic liver disease, and imaging plays important role in detection of complications and ruling out other possible causes of chronic liver disease. Emerging techniques such as elastography provide non-invasive options for diagnosis of significant fibrosis and cirrhosis during clinical follow-up as well as assessment of response to treatment. In this study, we will describe imaging findings in AIH and overlap syndromes.