Differential Pulse-Adsorptive Cathodic Stripping Voltammetric Determination of Sulfadiazine Drug in Pharmaceutical Formulations and Drug Residue in Wastewater at a Hanging Mercury Dropping Electrode

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• 作者：A. S. Bashammakh
• 关键词：Sulfadiazine determination ; Adsorptive stripping voltammetry ; Electrode mechanism ; Pharmaceutical formulations ; Drug residue
• 刊名：Arabian Journal for Science and Engineering
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：42
• 期：1
• 页码：183-192
• 全文大小：
• 刊物类别：Engineering
• 刊物主题：Engineering, general; Science, Humanities and Social Sciences, multidisciplinary;
• 出版者：Springer Berlin Heidelberg
• ISSN：2191-4281
• 卷排序：42

文摘

An adsorptive differential pulse cathodic stripping voltammetry method has been developed for determining the presence of sulfadiazine drugs. The method is based upon the adsorptive collection of the drug on a hanging mercury dropping electrode at −1.0 V versus Ag/AgCl reference electrode. Factors affecting the stripping performance such as, pH, accumulation time and potential, sweep rate were critically studied. The optimum conditions were achieved in a Britton–Robinson buffer of pH 5–6. At the optimal conditions, the cathodic stripping current of the drug at −1.0 V versus concentrations was linear in the concentration range \({3.7 \times 10^{-9}}\) –\({1.0 \times 10^{-7}\;{\rm mol L}^{-1}}\). The lower limit of detection and quantification of the drug were \({1.1 \times 10^{-9}}\) and \({3.7 \times 10^{-9} {\rm mol L}^{-1}}\), respectively. The method was successfully applied for the determination of industrial wastewater, pure form (\({98.2 \pm 3.1}\) %) and drug formulations (\({98.3 \pm 2.9}\) %). The method was validated by comparison with the standard HPLC and the reported methods. The method offers a simple system, coupled with good reproducibility, accuracy, ruggedness, and cost-effectiveness.