SOHSite: incorporating evolutionary information and physicochemical properties to identify protein S-sulfenylation sites

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• 作者：Van-Minh Bui ; Shun-Long Weng ; Cheng-Tsung Lu ; Tzu-Hao Chang…
• 关键词：S ; sulfenylation ; Sulfenic acids ; Support vector machine ; Physicochemical properties
• 刊名：BMC Genomics
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：17
• 期：1-supp
• 全文大小：2,248 KB
• 刊物主题：Life Sciences, general; Microarrays; Proteomics; Animal Genetics and Genomics; Microbial Genetics and Genomics; Plant Genetics & Genomics;
• 出版者：BioMed Central
• ISSN：1471-2164

文摘

Background Protein S-sulfenylation is a type of post-translational modification (PTM) involving the covalent binding of a hydroxyl group to the thiol of a cysteine amino acid. Recent evidence has shown the importance of S-sulfenylation in various biological processes, including transcriptional regulation, apoptosis and cytokine signaling. Determining the specific sites of S-sulfenylation is fundamental to understanding the structures and functions of S-sulfenylated proteins. However, the current lack of reliable tools often limits researchers to use expensive and time-consuming laboratory techniques for the identification of S-sulfenylation sites. Thus, we were motivated to develop a bioinformatics method for investigating S-sulfenylation sites based on amino acid compositions and physicochemical properties.