Bone mineral density in juvenile onset Systemic lupus erythematosus

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• 作者：Reem Abdwani (1)
  E. Abdulla (1)
  S. Yaroubi (1)
  H. Bererhi (2)
  I. Al-Zakwani (3)
  
  1. Departments of Child Health ; Sultan Qaboos University Hospital ; Muscat ; Oman
  2. Departments of Radiology and Clinical Pharmacy ; Sultan Qaboos University Hospital ; Muscat ; Oman
  3. Departments of Pharmacology and Clinical Pharmacy ; Sultan Qaboos University Hospital ; Muscat ; Oman
  
• 关键词：Bone mass ; Osteopenia ; Vitamin D
• 刊名：Indian Pediatrics
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：52
• 期：1
• 页码：38-40
• 全文大小：445 KB
• 参考文献：1. Sinigaglia L, Varenn Ma, Binelli L, Zucchi F, Ghiringhelli D, Fantini F. Bone mass in systemic lupus erythematosus. Clin Exp Rheumatol. 2000:18:S27鈥揝34.
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  9. Alsufyani KA, Ortiz-Alvarez O, Cabral DA, Tucker LB, Petty RE, Nadel H, / et al. Bone mineral density in children and adolescents with systemic lupus erythematosus, juvenile dermatomyositis, and systemic vasculitis: Relationship to disease duration, cumulative corticosteroid dose, calcium intake, and exercise. J Rheumatol. 2005;32:729鈥?3.
  10. Lim SH, Bensler SM, Tyrrell PN, Charron M, Harvey E, Hebert D, / et al. Low bone mineral density is present in newly diagnosed paediatric systemic lupus erythematosus patients. Ann Rheum Dis. 2011;70:1991鈥?. href="http://dx.doi.org/10.1136/ard.2010.144311" target="_blank" title="It opens in new window">CrossRef
  11. Bonakdar ZS, Jahanshahifar L, Jahanshahifar F, Gholamrezaei A. Vitamin D deficiency and its association with disease activity in new cases of systemic lupus erythematosus. Lupus. 2011;20:1155鈥?0. href="http://dx.doi.org/10.1177/0961203311405703" target="_blank" title="It opens in new window">CrossRef
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• 刊物主题：Pediatrics; Pediatric Surgery; Maternal and Child Health;
• 出版者：Springer India
• ISSN：0974-7559

文摘

Objective To compare bone mineral density in patients with juvenile-onset Systemic lupus erythematosus and healthy controls. Participants Serial bone mineral density measurements in 27 patients with juvenile-onset systemic lupus were compared to 97 healthy age-matched controls. Results All patients with juvenile-onset had low bone mineral density scores at initial assessment that progressed over disease course. Low body mass index was independently associated with a decline in bone mineral density Z scores; disease activity, use of immunosuppressive agents and vitamin D levels were not risk factors. Conclusion Patients with juvenile-onset systemic lupus erythematosus have low bone mineral density.