Spinal cholinergic mechanism of the relieving effects of electroacupuncture on cold and warm allodynia in a rat model of neuropathic pain
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- 作者：Jung Hyuk Park (1) (5)
Sun Kwang Kim (2) (3)
Ha Neul Kim (1) (5)
Boram Sun (1)
Sungtae Koo (6)
Sun Mi Choi (6)
Hyunsu Bae (2) (3)
Byung-Il Min (1) (4) - 关键词：Neuropathic pain ; Allodynia ; Electroacupuncture ; Spinal cord ; Cholinergic ; Muscarinic
- 刊名：The Journal of Physiological Sciences
- 出版年：2009
- 出版时间：July 2009
- 年：2009
- 卷：59
- 期：4
- 页码：291-298
- 全文大小：354KB
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Sun Kwang Kim (2) (3)
Ha Neul Kim (1) (5)
Boram Sun (1)
Sungtae Koo (6)
Sun Mi Choi (6)
Hyunsu Bae (2) (3)
Byung-Il Min (1) (4)
1. Department of East-West Medicine, Graduate School, Kyung Hee University, Seoul, 130-701, South Korea
5. Jaseng Hospital of Oriental Medicine, Seoul, South Korea
2. Department of Physiology, College of Oriental Medicine, Kyung Hee University, Seoul, 130-701, South Korea
3. BK21 Oriental Medical Science Center, Kyung Hee University, Seoul, 130-701, South Korea
6. Department of Medical Research, Korea Institute of Oriental Medicine, Daejeon, 305-811, South Korea
4. Department of Physiology, College of Medicine, Kyung Hee University, No. 1 Hoegi-Dong, Dongdaemoon-Gu, Seoul, 130-701, South Korea - ISSN：1880-6562
文摘
This study was performed to determine whether spinal cholinergic systems mediate the relieving effects of electroacupuncture (EA) on cold and warm allodynia in a rat model of neuropathic pain. For neuropathic surgery, the right superior caudal trunk was resected at the level between the S1 and S2 spinal nerves innervating the tail. Two weeks after the injury, the intrathecal (i.t.) catheter was implanted. Five days after the catheterization, the rats were injected with atropine (non-selective muscarinic antagonist, 30?μg), mecamylamine (non-selective nicotinic antagonist, 50?μg), pirenzepine (M1 muscarinic antagonist, 10?μg), methoctramine (M2 antagonist, 10?μg) or 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP) (M3 antagonist, 10?μg). Ten minutes after the injection, EA was applied to the ST36 acupoint for 30?min. The cold and warm allodynia were assessed by the tail immersion test [i.e., immersing the tail in cold (4°C) or warm (40°C) water and measuring the latency of an abrupt tail movement] before and after the treatments. The i.t. atropine, but not mecamylamine, blocked the relieving effects of EA on cold and warm allodynia. Furthermore, i.t. pirenzepine attenuated the antiallodynic effects of EA, whereas methoctramine and 4-DAMP did not. These results suggest that spinal muscarinic receptors, especially M1 subtype, mediate the EA-induced antiallodynia in neuropathic rats.