MRI of High-Glucose Metabolism Tumors: a Study in Cells and Mice with 2-DG-Modified Superparamagnetic Iron Oxide Nanoparticles

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• 作者：Xiu Hong Shan ; Peng Wang ; Fei Xiong ; Ning Gu ; Hui Hu…
• 关键词：2 ; Deoxy ; d ; glucose ; Superparamagnetic iron oxide ; Glucose metabolism ; Breast cancer ; Magnetic resonance imaging
• 刊名：Molecular Imaging and Biology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：18
• 期：1
• 页码：24-33
• 全文大小：8,712 KB
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• 作者单位：Xiu Hong Shan (1)
  Peng Wang (1)
  Fei Xiong (3)
  Ning Gu (3)
  Hui Hu (1)
  Wei Qian (1)
  Hao Yue Lu (4)
  Yu Fan (2)
  
  1. Department of Radiology, The Affiliated Renmin Hospital of Jiangsu University, Zhenjiang, 212002, China
  3. State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory of Biomaterials and devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210009, China
  4. Medical college, Jiangsu University, Zhenjiang, 212013, China
  2. Oncology Institute, The Affiliated Renmin Hospital of Jiangsu University, Zhenjiang, 212002, China
  
• 刊物主题：Imaging / Radiology;
• 出版者：Springer US
• ISSN：1860-2002

文摘

Purpose This study aims to evaluate the effect of dimercaptosuccinic acid (DMSA)-coated superparamagnetic iron oxide (γ-Fe₂O₃@DMSA) bearing the 2-deoxy-d-glucose (2-DG) ligand on targeting tumors with high-glucose metabolism.