Parallel artificial liquid membrane extraction of acidic drugs from human plasma

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• 作者：Mercedes Roldán-Pijuán ; Stig Pedersen-Bjergaard…
• 关键词：Parallel artificial liquid membrane extraction ; Liquid ; liquid extraction ; 96 ; Well plates ; Supported liquid membrane ; Human plasma ; Acidic drugs
• 刊名：Analytical and Bioanalytical Chemistry
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：407
• 期：10
• 页码：2811-2819
• 全文大小：1,192 KB
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• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Analytical Chemistry
  Food Science
  Inorganic Chemistry
  Physical Chemistry
  Monitoring, Environmental Analysis and Environmental Ecotoxicology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1618-2650

文摘

The new sample preparation concept “Parallel artificial liquid membrane extraction (PALME)-was evaluated for extraction of the acidic drugs ketoprofen, fenoprofen, diclofenac, flurbiprofen, ibuprofen, and gemfibrozil from human plasma samples. Plasma samples (250?μL) were loaded into individual wells in a 96-well donor plate and diluted with HCl to protonate the acidic drugs. The acidic drugs were extracted as protonated species from the individual plasma samples, through corresponding artificial liquid membranes each comprising 2?μL of dihexyl ether, and into corresponding acceptor solutions each comprising 50?μL of 25?mM ammonia solution (pH?10). The liquid membranes and the acceptor solutions were located in a 96-well filter plate, which was sandwiched with the 96-well donor plate during extraction. Parallel extraction of several samples was performed for 15 to 60?min, followed by high-performance liquid chromatography-ultraviolet detection of the individual acceptor solutions. Important PALME parameters including the chemical composition of the liquid membrane, extraction time, and sample pH were optimized, and the extraction performance was evaluated. Except for flurbiprofen, exhaustive extraction was accomplished from plasma. Linearity was obtained for all six drugs in the range 0.025-0?μg/mL, with r 2 values ranging between 0.998 and 1.000. Precision data were in the range 3-2?% RSD, and accuracy data were within 72-30?% with spiked plasma samples. Based on the current experiences, PALME showed substantial potential for future high-throughput bioanalysis of non-polar acidic drugs.