4-D flow magnetic resonance imaging: blood flow quantification compared to 2-D phase-contrast magnetic resonance imaging and Doppler echocardiography

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• 作者：Maya Gabbour ; Susanne Schnell ; Kelly Jarvis ; Joshua D. Robinson…
• 关键词：Cardiovascular magnetic resonance ; 4 ; D flow ; Phase ; contrast ; Magnetic resonance imaging ; Pediatric ; Congenital heart disease
• 刊名：Pediatric Radiology
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：45
• 期：6
• 页码：804-813
• 全文大小：1,490 KB
• 参考文献：1.Atkinson DJ, Edelman RR (1991) Cineangiography of the heart in a single breath hold with a segmented turboFLASH sequence. Radiology 178:357-60View Article PubMed
  2.Beerbaum P, Korperich H, Barth P et al (2001) Noninvasive quantification of left-to-right shunt in pediatric patients: phase-contrast cine magnetic resonance imaging compared with invasive oximetry. Circulation 103:2476-482View Article PubMed
  3.Chai P, Mohiaddin R (2005) How we perform cardiovascular magnetic resonance flow assessment using phase-contrast velocity mapping. J Cardiovasc Magn Reson 7:705-16PubMed
  4.Didier D (2003) Assessment of valve disease: qualitative and quantitative. Magn Reson Imaging Clin N Am 11:115-34View Article PubMed
  5.Gatehouse PD, Keegan J, Crowe LA et al (2005) Applications of phase-contrast flow and velocity imaging in cardiovascular MRI. Eur Radiol 15:2172-184View Article PubMed
  6.Pelc NJ, Bernstein MA, Shimakawa A et al (1991) Encoding strategies for three-direction phase-contrast MR imaging of flow. J Magn Reson Imaging 1:405-13View Article PubMed
  7.Underwood SR, Firmin DN, Klipstein RH et al (1987) Magnetic resonance velocity mapping: clinical application of a new technique. Br Heart J 57:404-12View Article PubMed Central PubMed
  8.Jung B, Honal M, Ullmann P et al (2008) Highly k-t-space-accelerated phase-contrast MRI. Magn Reson Med 60:1169-177View Article PubMed
  9.Uribe S, Beerbaum P, Sorensen TS et al (2009) Four-dimensional (4D) flow of the whole heart and great vessels using real-time respiratory self-gating. Magn Reson Med 62:984-92View Article PubMed
  10.Hsiao A, Lustig M, Alley MT et al (2012) Rapid pediatric cardiac assessment of flow and ventricular volume with compressed sensing parallel imaging volumetric cine phase-contrast MRI. AJR Am J Roentgenol 198:W250-59View Article PubMed Central PubMed
  11.Tariq U, Hsiao A, Alley M et al (2013) Venous and arterial flow quantification are equally accurate and precise with parallel imaging compressed sensing 4D phase contrast MRI. J Magn Reson Imaging 37:1419-426View Article PubMed Central PubMed
  12.Schnell S, Markl M, Entezari P et al (2014) k-t GRAPPA accelerated four-dimensional flow MRI in the aorta: effect on scan time, image quality, and quantification of flow and wall shear stress. Magn Reson Med 72:522-33View Article PubMed Central PubMed
  13.Bachler P, Valverde I, Pinochet N et al (2013) Caval blood flow distribution in patients with Fontan circulation: quantification by using particle traces from 4D flow MR imaging. Radiology 267:67-5View Article PubMed
  14.Francois CJ, Srinivasan S, Schiebler ML et al (2012) 4D cardiovascular magnetic resonance velocity mapping of alterations of right heart flow patterns and main pulmonary artery hemodynamics in tetralogy of Fallot. J Cardiovasc Magn Reson 14:16View Article PubMed Central PubMed
  15.Frydrychowicz A, Markl M, Hirtler D et al (2011) Aortic hemodynamics in patients with and without repair of aortic coarctation: in vivo analysis by 4D flow-sensitive magnetic resonance imaging. Invest Radiol 46:317-25PubMed
  16.Geiger J, Hirtler D, Burk J et al (2014) Postoperative pulmonary and aortic 3D haemodynamics in patients after repair of transposition of the great arteries. Eur Radiol 24:200-08View Article PubMed Central PubMed
  17.Geiger J, Markl M, Jung B et al (2011) 4D-MR flow analysis in patients after repair for tetralogy of Fallot. Eur Radiol 21:1651-657View Article PubMed
  18.Markl M, Geiger J, Jung B et al (2012) Noninvasive evaluation of 3D hemodynamics in a complex case of single ventricle physiology. J Magn Reson Imaging 35:933-37View Article PubMed
  19.Uribe S, Bachler P, Valverde I et al (2013) Hemodynamic assessment in patients with one-and-a-half ventricle repair revealed by four-dimensional flow magnetic resonance imaging. Pediatr Cardiol 34:447-51View Article PubMed
  20.Valverde I, Simpson J, Schaeffter T et al (2010) 4D phase-contrast flow cardiovascular magnetic resonance: comprehensive quantification and visualization of flow dynamics in atrial septal defect and partial anomalous pulmonary venous return. Pediatr Cardiol 31:1244-248View Article PubMed
  21.Hsiao A, Alley MT, Massaband P et al (2011) Improved cardiovascular flow quantification with time-resolved volumetric phase-contrast MRI. Pediatr Radiol 41:711-20View Article PubMed
  22.Nordmeyer S, Riesenkampff E, Crelier G et al (2010) Flow-sensitive four-dimensional cine magnetic resonance imaging for offline blood flow quantification in multiple vessels: a validation study. J Magn Reson Imaging 32:677-83View Article PubMed
  23.Nordmeyer S, Riesenkampff E, Messroghli D et al (2013) Four-dimensional velocity-encoded magnetic resonance imaging improves blood flow quantification in patients with complex accelerated flow. J Magn Reson Imaging 37:208-16View Article PubMed
  24.Valverde I, Nordmeyer S, Uribe S et al (2012) Systemic-to-pulmonary c
• 作者单位：Maya Gabbour (1)
  Susanne Schnell (2)
  Kelly Jarvis (3)
  Joshua D. Robinson (4) (5)
  Michael Markl (2) (3)
  Cynthia K. Rigsby (1) (2)
  
  1. Department of Medical Imaging #9, Ann & Robert H. Lurie Children’s Hospital of Chicago, 225 E. Chicago Ave., Chicago, IL, 60611, USA
  2. Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
  3. Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, USA
  4. Department of Pediatrics, Division of Pediatric Cardiology, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA
  5. Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Imaging and Radiology
  Pediatrics
  Neuroradiology
  Nuclear Medicine
  Ultrasound
  Oncology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1998

文摘

Background Doppler echocardiography (echo) is the reference standard for blood flow velocity analysis, and two-dimensional (2-D) phase-contrast magnetic resonance imaging (MRI) is considered the reference standard for quantitative blood flow assessment. However, both clinical standard-of-care techniques are limited by 2-D acquisitions and single-direction velocity encoding and may make them inadequate to assess the complex three-dimensional hemodynamics seen in congenital heart disease. Four-dimensional flow MRI (4-D flow) enables qualitative and quantitative analysis of complex blood flow in the heart and great arteries. Objectives The objectives of this study are to compare 4-D flow with 2-D phase-contrast MRI for quantification of aortic and pulmonary flow and to evaluate the advantage of 4-D flow-based volumetric flow analysis compared to 2-D phase-contrast MRI and echo for peak velocity assessment in children and young adults. Materials and methods Two-dimensional phase-contrast MRI of the aortic root, main pulmonary artery (MPA), and right and left pulmonary arteries (RPA, LPA) and 4-D flow with volumetric coverage of the aorta and pulmonary arteries were performed in 50 patients (mean age: 13.1?±-.4?years). Four-dimensional flow analyses included calculation of net flow and regurgitant fraction with 4-D flow analysis planes similarly positioned to 2-D planes. In addition, 4-D flow volumetric assessment of aortic root/ascending aorta and MPA peak velocities was performed and compared to 2-D phase-contrast MRI and echo. Results Excellent correlation and agreement were found between 2-D phase-contrast MRI and 4-D flow for net flow (r--.97, P-lt;-.001) and excellent correlation with good agreement was found for regurgitant fraction (r--.88, P-lt;-.001) in all vessels. Two-dimensional phase-contrast MRI significantly underestimated aortic (P--.032) and MPA (P-lt;-.001) peak velocities compared to echo, while volumetric 4-D flow analysis resulted in higher (aortic: P--.001) or similar (MPA: P--.98) peak velocities relative to echo. Conclusion Excellent flow parameter agreement between 2-D phase-contrast MRI and 4-D flow and the improved volumetric 4-D flow velocity analysis relative to echo suggests that 4-D flow has the potential to become a clinical alternative to 2-D phase-contrast MRI.