Cytoprotective mechanisms in rats lung parenchyma with zinc deprivation
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- 作者：Verónica S. Biaggio (1)
Daiana G. Alvarez-Olmedo (5)
María V. Perez Chaca (1)
Natalia R. Salvetti (2)
Susana R. Valdez (3) (4)
Mariel A. Fanelli (5)
Hugo H. Ortega (2)
Nidia N. Gomez (1)
María S. Gimenez (1) - 关键词：Cytoprotective mechanism ; Zn deficiency ; Lung
- 刊名：Biometals
- 出版年：2014
- 出版时间：April 2014
- 年：2014
- 卷：27
- 期：2
- 页码：305-315
- 全文大小：3,311 KB
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Daiana G. Alvarez-Olmedo (5)
María V. Perez Chaca (1)
Natalia R. Salvetti (2)
Susana R. Valdez (3) (4)
Mariel A. Fanelli (5)
Hugo H. Ortega (2)
Nidia N. Gomez (1)
María S. Gimenez (1)
1. Laboratorio de Química Biológica, Departamento de Bioquímica y Ciencias Biológicas, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, IMIBIO-CONICET, Chacabuco y Pedernera, 5700, San Luis, Argentina
5. Laboratorio de Oncología, IMBECU (CCT), CONICET, Mendoza, Argentina
2. Departamento de Ciencias Morfológicas, Facultad de Ciencias Veterinarias, Universidad Nacional del Litoral, ICIVET-LITORAL, UNL/CONICET, Esperanza, Santa Fe, Argentina
3. Instituto de Ciencias Básicas, Universidad Nacional de Cuyo, Mendoza, Argentina
4. Laboratorio de Reproducción y Lactancia, IMBECU (CCT), CONICET, Mendoza, Argentina - ISSN：1572-8773
文摘
Suboptimal intake of Zinc (Zn) is one of the most common worldwide nutritional problems. The aim of this study is to provide new evidence on the relation between moderate Zn restriction, and cytoprotective functions in airway epithelium. We analyzed the effect of moderate Zn deficiency (ZD) on the expression of several pro and anti-apoptotic proteins and cytoprotective factors (Hsp27 and Hsp 70i), as well as the effect of restoring Zn during the refeeding period. Adult male rats were divided into three groups: Zn-adequate control group, Zn-deficient group and Zn-refed group. Our previous findings showed an important oxidative and nitrosative stress during ZD, this situation is accompanied by inflammation and alterations in the expression of matrix extracellular proteins. We observed a strong immunopositive area of anti and pro-apoptotics proteins in ZD groups. The mRNA levels of Nrf-2, Bax and Bad were increased in ZD, while in ZD refed group its levels were similar to the control values. The increased expression of Nrf-2 is likely to be critical for protection of lung under inflammatory process triggered during ZD. Hsp27 and Hsp 70i showed an increase of immunostaining area but they were not significant. During the supplementation period, heat-shock proteins increased significantly. In conclusion, our results provide further evidence of the pathways involved in cytoprotection and apoptosis caused by ZD. Additional studies are required in order to investigate whether Hsp27 and Hsp70 are consistently associated with cellular stress and inflammation in lung. There may be a beneficial role for improved Zn nutrition or Zn supplements early in lung pathology.