Mapping the Connectome Following Traumatic Brain Injury
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  • 作者：Yousef Hannawi ; Robert D. Stevens
  • 关键词：Amyloid beta ; Arterial spin labeling ; Cognition ; Coma ; Diffusion tensor imaging ; Diffusion ; weighted imaging ; Electroencephalography ; Functional magnetic resonance imaging ; Neurologic recovery ; Magnetic resonance imaging ; Magnetic resonance spectroscopy ; Magnetoencephalography ; Neural plasticity ; Positron imaging tomography ; Susceptibility ; weighted imaging ; Tau protein ; Translocator protein ; Traumatic axonal injury ; Traumatic brain injury
  • 刊名：Current Neurology and Neuroscience Reports
  • 出版年：2016
  • 出版时间：May 2016
  • 年：2016
  • 卷：16
  • 期：5
  • 全文大小：1,277 KB
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  • 作者单位：Yousef Hannawi (1)
    Robert D. Stevens (2) (3) (4) (5) (6)

    1. Division of Cerebrovascular Diseases and Neurocritical Care, Department of Neurology, The Ohio State University, Columbus, OH, USA
    2. Division of Neurosciences Critical Care, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    3. Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    4. Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    5. Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    6. Division of Neuroscience Critical Care, Johns Hopkins University School of Medicine, 600 N. Wolfe St, Phipps 455, Baltimore, MD, 21287, USA
  • 刊物主题：Neurology; Neurosciences;
  • 出版者：Springer US
  • ISSN：1534-6293
    • 文摘
    There is a paucity of accurate and reliable biomarkers to detect traumatic brain injury, grade its severity, and model post-traumatic brain injury (TBI) recovery. This gap could be addressed via advances in brain mapping which define injury signatures and enable tracking of post-injury trajectories at the individual level. Mapping of molecular and anatomical changes and of modifications in functional activation supports the conceptual paradigm of TBI as a disorder of large-scale neural connectivity. Imaging approaches with particular relevance are magnetic resonance techniques (diffusion weighted imaging, diffusion tensor imaging, susceptibility weighted imaging, magnetic resonance spectroscopy, functional magnetic resonance imaging, and positron emission tomographic methods including molecular neuroimaging). Inferences from mapping represent unique endophenotypes which have the potential to transform classification and treatment of patients with TBI. Limitations of these methods, as well as future research directions, are highlighted.

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