Polysaccharides/mesoporous silica nanoparticles hybrid composite hydrogel beads for sustained drug delivery

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• 作者：Yan Hu ; Xiaoying Dong ; Lei Ke ; Shangwen Zhang ; Dan Zhao…
• 刊名：Journal of Materials Science
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：52
• 期：6
• 页码：3095-3109
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Materials Science, general; Characterization and Evaluation of Materials; Polymer Sciences; Continuum Mechanics and Mechanics of Materials; Crystallography and Scattering Methods; Classical Mechanics;
• 出版者：Springer US
• ISSN：1573-4803
• 卷排序：52

文摘

A simple and effective route was established to regulate the drug release kinetics of hydrogels through a combination method of the polysaccharides matrix which delivers the drug and the mesoporous silica nanoparticles (MSN) as a reservoir, making the system release the payload in a controlled manner. The composite MSN beads can construct one kind of novel sustained drug administration device maintaining 24 h activity. With the increase of the MSN ratio in the beads, the sustained-release profile can be increased. The drug release kinetics provide clear evidence that the composite MSN beads delivery systems can protect the model drug of bovine serum albumin from external denaturants and release them slowly in a predictable model. These composite MSN beads with higher drug-loading capacity and better retention ability may facilitate sustained/controlled drug delivery systems for pharmaceutical and biomedical applications.