Mechanical properties and in vitro degradation of PLGA suture manufactured via electrospinning

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• 作者：Fatemeh Haghighat (1)
  Seyed Abdolkarim Hosseini Ravandi (1) (2)
  
• 关键词：Nanofiber yarn ; Suture ; Morphology ; Mechanical properties ; Degradation
• 刊名：Fibers and Polymers
• 出版年：2014
• 出版时间：January 2014
• 年：2014
• 卷：15
• 期：1
• 页码：71-77
• 全文大小：634 KB
• 作者单位：Fatemeh Haghighat (1)
  Seyed Abdolkarim Hosseini Ravandi (1) (2)
  
  1. Department of Textile Engineering, Isfahan University of Technology, 84156 83111, Isfahan, Iran
  2. Nanotechnology & Advanced Materials Institute, Department of Textile Engineering, Isfahan University of Technology, 84156 83111, Isfahan, Iran
  
• ISSN：1875-0052

文摘

The current research discusses the efforts to achieve a Poly(lactide-co-glycolide)(PLGA) nanofiber yarn using two differently charged nozzles with potential application as surgery suture. First, electrospinning parameters such as solution concentration, applied voltage, feed rate were optimized to produce yarn with smooth nanofibers. In order to improve the properties of produced suture, heat setting setup was developed. Two heat setting techniques, including hot water and dry heat were applied, and the influence of the heat setting process on the mechanical properties of yarn was studied. The results showed that heat setting with boiling water was the best method. At first strength, E-modulus and extension of prepared suture were 36.6 MPa, 0.9 GPa and 68.8 % respectively. After improvement with heat setting, strength and E-modulus increased to 63.7 MPa, 2.7 GPa respectively and extension decreased to 29.7 %. Finally, in order to analyze knot performance, two types of surgical knot (square and surgeon) were used, and mechanical properties were investigated. The presence of knot lessens mechanical properties for each two type. Square knot showed better mechanical properties than surgeon’s knot. With square knot strength, E-modulus and extension were 62.1 MPa, 2.1 GPa, 28.6 %, respectively. In vitro study of nanofiber yarn degradation behavior showed that the mechanical properties were decreased. This could be due to greater surface area of nanofibers exposed to surrounding environment.