Superfluorinated copper sulfide nanoprobes for simultaneous 19F magnetic resonance imaging and photothermal ablation

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• 作者：Gaofei Hu ; Juan Tang ; Xilin Bai ; Suying Xu ; Leyu Wang
• 刊名：Nano Research
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：9
• 期：6
• 页码：1630-1638
• 全文大小：1,563 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chinese Library of Science
  Chemistry
  Nanotechnology
  
• 出版者：Tsinghua University Press, co-published with Springer-Verlag GmbH
• ISSN：1998-0000
• 卷排序：9

文摘

Copper sulfide (Cu₇S₄) nanoparticles coated with an ultra-high payload (~5.0 × 107 fluorine atoms per particle) of fluorinated ligands (oleylamine functionalized 3,5-bis(trifluoromethyl)benzaldehyde, 19F_OAm) exhibited a single intense 19F magnetic resonance (MR) signal and efficient near infrared photothermal performance in water medium. In vivo assessment revealed strong 19F MR signals at cancerous lesions and effective inhibition of tumor growth after photothermal treatment, indicating the great potential of these fabricated nanoprobes for simultaneous 19F MR imaging and photothermal therapy.