New monoclonal antibodies to the Ebola virus glycoprotein: Identification and analysis of the amino acid sequence of the variable domains

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• 作者：A. A. Panina ; T. K. Aliev ; O. B. Shemchukova…
• 刊名：Doklady Biochemistry and Biophysics
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：467
• 期：1
• 页码：117-120
• 全文大小：486 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Biophysics and Biomedical Physics
  Russian Library of Science
  
• 出版者：MAIK Nauka/Interperiodica distributed exclusively by Springer Science+Business Media LLC.
• ISSN：1608-3091
• 卷排序：467

文摘

We determined the nucleotide and amino acid sequences of variable domains of three new monoclonal antibodies to the glycoprotein of Ebola virus capsid. The framework and hypervariable regions of immunoglobulin heavy and light chains were identified. The primary structures were confirmed using massspectrometry analysis. Immunoglobulin database search showed the uniqueness of the sequences obtained.Original Russian Text © A.A. Panina, T.K. Aliev, O.B. Shemchukova, I.G. Dement’yeva, N.E. Varlamov, L.P. Pozdnyakova, M.N. Bokov, D.A. Dolgikh, P.G. Sveshnikov, M.P. Kirpichnikov, 2016, published in Doklady Akademii Nauk, 2016, Vol. 467, No. 4, pp. 477–480.