Hypothalamic–Pituitary–Adrenal Activity Among Armenian Adolescents with PTSD Symptoms

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• 作者：Goenjian ; Armen K. ; Pynoos ; Robert S. ; Steinberg ; Alan M. ; Endres ; David ; Abraham ; Khachik ; Geffner ; Mitchell E. ; Fairbanks ; Lynn A.
• 关键词：trauma ; PTSD ; cortisol ; ACTH ; growth hormone ; TSH
• 刊名：Journal of Traumatic Stress
• 出版年：2003
• 出版时间：2003
• 年：2003
• 卷：16
• 期：4
• 页码：319-323
• 全文大小：35 KB
• 刊物类别：Behavioral Science
• 刊物主题：Psychology
  Stress and Coping
  Clinical Psychology
  Psychiatry
  Personality and Social Psychology
  Public Health
  
• 出版者：Springer Netherlands
• ISSN：1573-6598

文摘

This study evaluated basal levels and responsiveness to exercise of plasma adrenocorticotropic hormone (ACTH), and serum thyroid stimulating hormone (TSH), growth hormone (GH) and cortisol among adolescents from two differentially exposed groups 6½ years after the 1988 earthquake in Armenia. Severity of total PTSD and Category C and D symptoms were negatively correlated with baseline cortisol. Preexercise ACTH was significantly lower, and preexercise TSH higher, among adolescents with more exposure. Depressive symptoms were negatively correlated with baseline cortisol and positively with TSH. Mean GH, TSH, and cortisol levels in both groups fell within normal limits. The pre- to postexercise increase in GH, TSH, and cortisol suggests that exercise challenge may be useful in the field investigation of neurohormonal activity among traumatized individuals.