Prognostic value of 18F-fluorodeoxyglucose PET-CT imaging in acute aortic syndromes: comparison with serological biomarkers of inflammation
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- 作者：Riccardo Gorla ; Raimund Erbel ; Hilmar Kuehl…
- 关键词：PET ; CT ; Acute aortic syndromes ; D ; dimer ; C ; reactive protein
- 刊名：The International Journal of Cardiovascular Imaging (formerly Cardiac Imaging)
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：31
- 期：8
- 页码：1677-1685
- 全文大小：1,003 KB
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Raimund Erbel (1) (8)
Hilmar Kuehl (2)
Philipp Kahlert (1)
Konstantinos Tsagakis (3)
Heinz Jakob (3)
Amir-Abbas Mahabadi (1)
Thomas Schlosser (4)
Andreas Bockisch (2)
Holger Eggebrecht (5)
Eduardo Bossone (6)
Rolf Alexander Jánosi (1)
1. Department of Cardiology, West-German Heart and Vascular Center Essen, University Duisburg-Essen, Essen, Germany
7. Cardiology Clinic, “Ospedale di Circolo-Varese, University of Insubria, Varese, Italy
8. West-German Heart and Vascular Center Essen, University Clinic of Cardiology, Hufelandstrasse 55, 45147, Essen, Germany
2. Department of Nuclear Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany
3. Department of Thoracic and Cardiovascular Surgery, West-German Heart and Vascular Center Essen, University Duisburg-Essen, Essen, Germany
4. Department of Radiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany
5. Cardioangiological Center Bethanien, Frankfurt am Main, Germany
6. “Heart-Department, University Hospital, Salerno, Italy - 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Cardiology - 出版者：Springer Netherlands
- ISSN：1573-0743
文摘
Aim of this study was to investigate the relationship between 18F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) findings and serological biomarkers of inflammation and the related discriminant value of unfavourable outcome during follow-up in patients with acute aortic syndromes (AAS). Sixty patients with AAS underwent PET-CT imaging during the hospitalization along with measurement of C-reactive protein (CRP) and D-dimer (D-d) serum levels. An aortic wall pathology was considered PET-positive by a maximum standardized uptake value (SUVmax) >2.5. A combined endpoint of major adverse events (MAE) including aorta-related mortality, disease progression and re-intervention was used to compare patient subgroups at 3-year follow-up. PET-CT detected an elevated FDG uptake within the aortic wall in 25 (41.7 %) patients. PET-positive patients showed significantly increased CRP levels (10.0 ± 6.6 mg/dL) and tended to higher D-d levels (5.1 ± 3.9 mg/L), compared to PET-negative patients (5.8 ± 6.1 mg/dL and 3.1 ± 4.7 mg/L respectively; P = 0.048, P = 0.19). At 3-year follow-up, all-cause mortality and MAE were higher in the PET-positive (21.7 and 47.8 % respectively) than PET-negative group (0.0 and 13.3 % respectively; P = 0.012, P = 0.006). On Kaplan–Meier analysis, PET-positive patients were at higher risk of MAE (P = 0.031). This tendency was more evident by combining PET results with D-d levels at a cutoff value of 4.8 mg/L (P < 0.001). In patients with AAS, a pathological glucose uptake in aortic wall lesions by PET-CT was associated with high CRP levels and increased mortality and MAE at 3-year follow-up. The combination of PET results with D-d levels had the best discriminant value of MAE. Keywords PET-CT Acute aortic syndromes D-dimer C-reactive protein