Homozygous haplotype deficiency reveals deleterious mutations compromising reproductive and rearing success in cattle
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- 作者：Hubert Pausch ; Hermann Schwarzenbacher ; Johann Burgstaller…
- 关键词：SLC2A2 ; SUGT1 ; Homozygous haplotype deficiency ; Fanconi ; Bickel syndrome ; Embryonic lethality
- 刊名：BMC Genomics
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：16
- 期：1
- 全文大小：1,749 KB
- 刊物主题：Life Sciences, general; Microarrays; Proteomics; Animal Genetics and Genomics; Microbial Genetics and Genomics; Plant Genetics & Genomics;
- 出版者：BioMed Central
- ISSN：1471-2164
文摘
Background Cattle breeding populations are susceptible to the propagation of recessive diseases. Individual sires generate tens of thousands of progeny via artificial insemination. The frequency of deleterious alleles carried by such sires may increase considerably within few generations. Deleterious alleles manifest themselves often by missing homozygosity resulting from embryonic/fetal, perinatal or juvenile lethality of homozygotes.