Insight into specific pro-arrhythmic triggers in Brugada and early repolarization syndromes: results of long-term follow-up
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- 作者：Ahmed Karim Talib ; Nobuyuki Sato ; Takuya Myojo ; Eitaro Sugiyama…
- 关键词：Early repolarization syndrome ; Brugada syndrome ; Pro ; arrhythmic triggers ; Steroid
- 刊名：Heart and Vessels
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：31
- 期：12
- 页码：2035-2044
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Cardiology; Cardiac Surgery; Vascular Surgery; Biomedical Engineering;
- 出版者：Springer Japan
- ISSN：1615-2573
- 卷排序：31
文摘
The pro-arrhythmic triggers in Brugada and early repolarization syndromes (BrS, ERS) have not been analyzed systematically except for case reports. We clinically investigated the circumstances which precede/predispose to arrhythmic events in these syndromes during long-term follow-up. A detailed history from the patients/witnesses was taken to investigate the antecedent events in the last few hours that preceded syncope/ventricular fibrillation (VF); medical records, ECG and blood test from the emergency room (ER) were reviewed. 19 patients that fulfilled the investigation criteria were followed up for 71 ± 49 months (34–190 months). Prior to the event (syncope/VF), the patients were partaking different activities in the following decreasing order; drinking alcoholic beverage, having meal, and getting up from sleep, exercise. 3 patients reported mental/physical stress prior to the event and 2 patients developed VF several days after starting oral steroid for treatment of bronchial asthma. In the ER, elevated J-wave amplitude (0.27 ± 0.15 mV) was found with 58 % of the patients having hypokalemia. After electrolyte correction and cessation of steroids, the following day plasma K+ (4.2 ± 0.3 mEq/L, P < 0.001) was significantly increased and J-wave amplitude (0.13 ± 0.1 mV, P < 0.001) was remarkably reduced. Three patients were kept on oral spironolactone/potassium supplements. During follow-up for 71 ± 49 (34–190) months, among 4 patients with VF recurrence, one patient developed VF after taking oral steroid. In ERS and BrS, hypokalemia and corticosteroid therapy add substantial pro-arrhythmic effects, but potentially treatable. Stopping steroid therapy and avoiding hypokalemia had excellent long-term outcome.