Early hyperreactive malarial splenomegaly and risk factors for evolution into the full-blown syndrome: a single-centre, retrospective, longitudinal study
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- 作者：Zeno Bisoffi ; Stefania Leoni ; Dora Buonfrate ; Claudia Lodesani…
- 关键词：Hyper ; reactive malarial splenomegaly ; Hyperreactive malarial splenomegaly ; Tropical splenomegaly ; Tropical splenomegaly syndrome ; HMS ; Early hyperreactive malarial splenomegaly ; e ; HMS ; Chronic malaria ; Malaria ; Plasmodium falciparum
- 刊名：Malaria Journal
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：14
- 期：1
- 全文大小：1,095 KB
- 刊物主题：Parasitology; Infectious Diseases; Tropical Medicine;
- 出版者：BioMed Central
- ISSN：1475-2875
文摘
Background The hyperreactive malarial splenomegaly (HMS) represents a chronic, potentially fatal complication of malaria. Case definition includes: gross splenomegaly, high level of anti-malarial antibody and IgM, response to long-term anti-malarial prophylaxis. In this study, a large series of patients not fully meeting the case definition was tentatively classified as early hyperreactive malarial splenomegaly (e-HMS). The main research questions was: does “e-HMS” tend to evolve to the full-blown syndrome? And if so, what are the main factors influencing this evolution?