Synthesis of 1-amidoalkyl-2-naphthols via three-component condensation of 2-naphthol, aldehydes, and amides/urea

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• 作者：M. Wang (1) minwangszg@yahoo.com.cn
  Y. Liang (1)
  T. T. Zhang (1)
  J. J. Gao (1)
• 关键词：amidoalkyl naphthols &#8211 ; multicomponent synthesis &#8211 ; tin tetrachloride &#8211 ; solvent ; free conditions
• 刊名：Chemistry of Natural Compounds
• 出版年：2012
• 出版时间：May 2012
• 年：2012
• 卷：48
• 期：2
• 页码：185-188
• 全文大小：74.5 KB
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• 作者单位：1. College of Chemistry and Chemical Engineering, Bohai University, Jinzhou, 121000 P. R. China
• 刊物类别：Medicine
• 刊物主题：Pharmacy
  Organic Chemistry
  Plant Sciences
  Russian Library of Science
  
• 出版者：Springer New York
• ISSN：1573-8388

文摘

An efficient three-component one-pot synthesis of 1-amidoalkyl-2-naphthols from 2-naphthol, aldehydes, and amides/urea using tin tetrachloride as catalyst at 80aC without solvent is described. The structures of the new compounds were characterized by IR, 1H NMR, and 13C NMR spectra and by elemental analysis. The advantages of the new method were good yields (45–97%), short reaction times (0.1–4 h), simple work-up, inexpensive catalyst, and the diversity of the method.