Oxidative stress and inflammation in obesity after taurine supplementation: a double-blind, placebo-controlled study

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• 作者：Flávia Troncon Rosa (1)
  Ellen Cristini Freitas (2)
  Rafael Deminice (3)
  Alceu Afonso Jord?o (1)
  Julio Sérgio Marchini (1)
  
• 关键词：Taurine ; Obesity ; Inflammation ; Oxidative stress ; Adiponectin
• 刊名：European Journal of Nutrition
• 出版年：2014
• 出版时间：April 2014
• 年：2014
• 卷：53
• 期：3
• 页码：823-830
• 全文大小：298 KB
• 参考文献：1. Global status report on noncommunicable diseases (2010) WHO Library Cataloguing-in-Publication Data
  2. Vincent HK, Taylor AG (2006) Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans. Int J Obes 30:400-18 CrossRef
  3. Gregor MF, Hotamisligil GS (2011) Inflammatory mechanisms in obesity. Annu Rev Immunol 29:415-45 CrossRef
  4. Hayes KC (1981) Taurine in metabolism. Annu Rev Nutr 1:401-25 CrossRef
  5. Stapleton PP, Charles RP, Redmond HP, Bouchier-Hayes DJ (1997) Taurine and human nutrition. Clin Nutr 16:103-08 CrossRef
  6. Ghandforoush-Sattari M, Mashayekhi S, Krishna CV, Thompson JP, Routledge PA (2010) Pharmacokinetics of oral taurine in healthy volunteers. J Amino Acids 2010:346237. doi:10.4061/2010/346237 CrossRef
  7. Jeevanandam M, Ramias L, Schiller WR (1991) Altered plasma free amino acid levels in obese traumatized man. Metabolism 40:385-90 CrossRef
  8. Tsuboyama-Kasaoka N, Shozawa C, Sano K, Kamei Y, Kasaoka S, Hosokawa Y, Ezaki O (2006) Taurine (2-aminoethanesulfonic acid) deficiency creates a vicious circle promoting obesity. Endocrinology 147:3276-284 CrossRef
  9. Marcinkiewicz J, Grabowska A, Bereta J, Stelmaszynska T (1995) Taurine chloramine, a product of activated neutrophils, inhibits in vitro the generation of nitric oxide and other macrophage inflammatory mediators. J Leukoc Biol 58:667-74
  10. Barua M, Liu Y, Quinn MR (2001) Taurine chloramine inhibits inducible nitric oxide synthase and tnf-α gene expression in activated alveolar macrophages: decreased NF-kB activation and IkkB kinase activity. J Immunol 167:2275-281
  11. Hwang DF, Hour JL, Cheng HM (2000) Effect of taurine on toxicity of oxidized fish oil in rats. Food Chem Toxicol 38:585-91 CrossRef
  12. Balkan J, Kanba?li O, Hatipo?lu A, Kücük M, Cevikba? U, Ayka?-Toker G, Uysal M (2002) Improving effect of dietary taurine supplementation on the oxidative stress and lipid levels in the plasma, liver and aorta of rabbits fed on a high-cholesterol diet. Biosci Biotechnol Biochem 66:1755-758 CrossRef
  13. Xiao C, Giacca A, Lewis GF (2008) Oral taurine but not / N-acetylcysteine ameliorates NEFA-induced impairment in insulin sensitivity and beta cell function in obese and overweight, non-diabetic men. Diabetologia 51:139-46 CrossRef
  14. Oliveira MW, Minotto JB, de Oliveira MR, Zanotto-Filho A, Behr GA, Rocha RF, Moreira JC, Klamt F (2010) Scavenging and antioxidant potential of physiological taurine concentrations against different reactive oxygen/nitrogen species. Pharmacol Rep 62:185-93 CrossRef
  15. Haber CA, Lam TK, Yu Z, Gupta N, Goh T, Bogdanovic E, Giacca A, Fantus IG (2003) N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress. Am J Physiol Endocrinol Metab 285:E744–E753
  16. Oprescu AI, Bikopoulos G, Naassan A, Allister EM, Tang C, Park E, Uchino H, Lewis GF, Fantus IG, Rozakis-Adcock M, Wheeler MB, Giacca A (2007) Free fatty acid–induced reduction in glucose-stimulated insulin secretion evidence for a role of oxidative stress in vitro and in vivo. Diabetes 56:2927-937 CrossRef
  17. Carneiro EM, Latorraca MQ, Araujo E, Beltrá M, Oliveras MJ, Navarro M, Berná G, Bedoya FJ, Velloso LA, Soria B, Martín F (2009) Taurine supplementation modulates glucose homeostasis and islet function. J Nutr Biochem 20:503-11 CrossRef
  18. Shao A, Hathcock JN (2008) Risk assessment for the amino acids taurine, l -glutamine and l -arginine. Reg Toxicol Pharmacol 50:376-99 CrossRef
  19. Costa CM, Santos RCC, Lima ES (2006) A simple automated procedure for thiol measurement in human serum samples. J Bras Patol Med Lab 42:345-50 CrossRef
  20. Benzie IFF, Strain JJ (1996) The ferric reducing ability of plasma (FRAP) as a measure of “Antioxidant Power- the FRAP assay. Anal Biochem 239:70-6 CrossRef
  21. Jord?o Júnior AA, Figueiredo JF, Silveira S, Junqueira-Franco MV, Vannucchi H (1998) Urinary excretion of vitamin A and thiobarbituric acid reactive substances in AIDS patients. Rev Hosp Clin Fac Med Sao Paulo 53:11-5
  22. Witko-Sarsat V, Friedlander M, Capeillère-Blandin C, Nguyen-Khoa T, Nguyen AT, Zingraff J, Jungers P, Descamps-Latscha B (1996) Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney Int 49:1304-313 CrossRef
  23. Deyl Z, Hyanek J, Horakova M (1986) Profiling of amino acids in body fluids and tissues by means of liquid chromatography. J Chromat 379:177-50 CrossRef
  24. Food and Nutrition Board: Institute of Medicine (2005) Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids (macronutrients). National Academy Press, Washington
  25. Rosa FT, Zulet MA, Marchini JS, Martínez JA (2012) Bioactive compounds with effects on inflammation markers in humans. Int J Food Sci Nutr 63:749-65 CrossRef
  26. Oudit GY, Trivieri MG, Khaper N, Husain T, Wilson GJ, Liu P, Sole MJ, Backx PH (2004) Taurine supplementation reduces oxidative stress and improves cardiovascular function in an iron-overload murine model. Circulation 109:1877-885 CrossRef
  27. Zhang M, Bi LF, Fang JH, Su XL, Da GL, Kuwamori T, Kagamimori S (2004) Beneficial effects of taurine on serum lipids in overweight or obese non-diabetic subjects. Amino Acids 26:267-71
  28. Parvez S, Tabassum H, Banerjee BD, Raisuddin S (2008) Taurine prevents tamoxifen-induced mitochondrial oxidative damage in mice. Basic Clin Pharmacol Toxicol 102:382-87 CrossRef
  29. Kim YG, Kim SK, Kwon JW, Park OJ, Kim SG, Kim YC, Lee MG (2003) Effects of cysteine on amino acid concentrations and transsulfuration enzyme activities in rat liver with protein–calorie malnutrition. Life Sci 72:1171-181 CrossRef
  30. Ouellet V, Weisnagel SJ, Marois J, Bergeron J, Julien P, Gougeon R, Tchernof A, Holub BJ, Jacques H (2008) Dietary cod protein reduces plasma c-reactive protein in insulin-resistant men and women. J Nutr 138:2386-391 CrossRef
  31. Ouellet V, Marois J, Weisnagel SJ, Jacques H (2007) Dietary cod protein improves insulin sensitivity in insulin-resistant men and women: a randomized controlled trial. Diabetes Care 30:2816-821 CrossRef
  32. Engeli S, Feldpausch M, Gorzelniak K, Hartwig F, Heintze U, Janke J, Mohlig M, Pfeiffer AFH, Luft FC, Sharma AM (2003) Association between adiponectin and mediators of inflammation in obese women. Diabetes 52:942-47 CrossRef
  33. Yuan G, Chen X, Ma Q, Qiao J, Li R, Li X, Li S, Tang J, Zhou L, Song H, Chen M (2007) C-reactive protein inhibits adiponectin gene expression and secretion in 3T3-L1 adipocytes. J Endocrinol 194:275-81 CrossRef
  34. Chen SW, Chen YX, Shi J, Lin Y, Xie WF (2006) The restorative effect of taurine on experimental nonalcoholic steatohepatitis. Dig Dis Sci 51:2225-234 CrossRef
  35. Chen X, Sebastian BM, Tang H, McMullen MM, Axhemi A, Jacobsen DW, Nagy LE (2009) Taurine supplementation prevents ethanol-induced decrease in serum adiponectin and reduces hepatic steatosis in rats. Hepatology 49:1554-562 CrossRef
  36. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Ushida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (2003) Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423:762-69 CrossRef
  37. Pajvani UB, Hawkins M, Combs TP, Rajala MW, Doebber T, Berger JP, Wagner JA, Wu M, Knopps A, Xiang AH, Utzschneider KM, Kahn SE, Olefsky JM, Buchanan TA, Scherer PE (2004) Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem 279:12152-2162 CrossRef
  38. Br?ns C, Spohr C, Storgaard H, Dyerberg J, Vaag A (2004) Effect of taurine treatment on insulin secretion and action, and on serum lipid levels in overweight men with a genetic predisposition for type II diabetes mellitus. Eur J Clin Nutr 58:1239-247 CrossRef
  
• 作者单位：Flávia Troncon Rosa (1)
  Ellen Cristini Freitas (2)
  Rafael Deminice (3)
  Alceu Afonso Jord?o (1)
  Julio Sérgio Marchini (1)
  
  1. Department of Internal Medicine, Faculty of Medicine of Ribeir?o Preto, University of S?o Paulo, Avenida Bandeirantes, 3900, Monte Alegre, Ribeir?o Preto, SP, CEP 14049-900, Brazil
  2. School of Physical Education and Sports of Ribeir?o Preto, University of S?o Paulo, Avenida Bandeirantes, 3900, Monte Alegre, Ribeir?o Preto, SP, CEP 14040-907, Brazil
  3. Institute of Physical Education and Sport, State University of Londrina, Rodovia Celso Garcia Cid, Pr 445?Km 380, Campus Universitário, Londrina, PR, CEP 86051-980, Brazil
  
• ISSN：1436-6215

文摘

Purpose Some researchers found decreased levels of plasma taurine in obese subjects and animals, and reduced expression of an important enzyme of taurine synthesis. These evidences, coupled with the metabolic imbalance of obesity and the possible anti-inflammatory and antioxidant effects of taurine, highlighted the use of taurine as a supplement in obesity treatment. The aim of the present study was to investigate whether taurine supplementation, associated with nutritional counseling, modulates oxidative stress, inflammatory response, and glucose homeostasis in obese women. Methods A randomized double-blind placebo-controlled study was conducted with 16 women with obesity diagnosis and 8 women in the normal weight range. The obese volunteers were matched by age and body mass index and randomly assigned to either the placebo (3?g/day starch flour) or taurine (3?g/day taurine) group. The study lasted 8?weeks, and the experimental protocol included nutritional assessment and determination of plasma sulfur amino acids, insulin, and adiponectin, serum glycemia, and markers of inflammatory response and oxidative stress. Results Plasma taurine levels were significantly decreased (41?%) in the obese volunteers. Both the placebo and taurine groups showed significant reduction in weight (3?%), with no differences between groups. Different from placebo, taurine-supplemented group showed significant increase in plasma taurine (97?%) and adiponectin (12?%) and significant reduction in the inflammatory marker hs-C-reactive protein (29?%) and in the lipid peroxidation marker thiobarbituric acid reactive substances (TBARS) (20?%). Conclusions Eight weeks of taurine supplementation associated with nutritional counseling is able to increase adiponectin levels and to decrease markers of inflammation (high-sensitivity C-reactive protein) and lipid peroxidation (TBARS) in obese women.