Simultaneous double thymic carcinoids: a rare initial manifestation of multiple endocrine neoplasia type 1

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• 作者：Ryutaro Kikuchi (1)
  Nobuya Mino (1)
  Taku Okamoto (1)
  Tadashi Matsukura (1)
  Takashi Hirai (1)
  
• 关键词：Thymic carcinoid ; Well ; differentiated neuroendocrine carcinoma of the thymus ; Multiple endocrine neoplasia type 1 (MEN ; 1) ; Surgical resection
• 刊名：General Thoracic and Cardiovascular Surgery
• 出版年：2011
• 出版时间：January 2011
• 年：2011
• 卷：59
• 期：1
• 页码：68-72
• 全文大小：418KB
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• 作者单位：Ryutaro Kikuchi (1)
  Nobuya Mino (1)
  Taku Okamoto (1)
  Tadashi Matsukura (1)
  Takashi Hirai (1)
  
  1. Division of Thoracic Surgery, Fukui Red Cross Hospital, 2-4-1 Tsukimi, Fukui, 918-8506, Japan
  

文摘

A 53-year-old man was referred to our hospital for treatment of two anterior mediastinal tumors. The anterior mediastinal tumors were resected by thymectomy under the probable diagnosis of double thymomas. The final pathological diagnosis was multiple thymic carcinoids. Although 20%-5% of patients with thymic carcinoid have a family history of multiple endocrine neoplasia type 1 (MEN-1), radiographic screening just after the operation did not detect any endocrine tumors. However, the patient had a urinary calculus 4 months 7 months after the operation. Endocrinological examination then revealed mild hypercalcemia, hypophosphatemia, hyperinsulinemia, and hyperprolactinemia. Radiologically, a parathyroid tumor and a pancreatic tumor were found. The patient was referred to a university hospital and a mutation of MEN-1 gene was detected. The diagnosis of MEN-1 was confirmed about 1 year after the operation.