Abdominal multivisceral transplantation in pigs

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• 作者：Teruo Komokata ; Seigo Nishida ; Seiji Ogata ; Nobuo Hamada ; Akira Ikoma ; Koki Tanaka ; Hiroki Yoshida and Akira Taira
• 关键词：Key words ; multiple organ procurement ; multivisceral transplantation ; pump perfusion
• 刊名：Journal of Hepato-Biliary-Pancreatic Surgery
• 出版年：2000
• 出版时间：April 2000
• 年：2000
• 卷：7
• 期：2
• 页码：188-192
• 全文大小：440 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Abdominal Surgery
  Surgical Oncology
  Gastroenterology
  Pathology
  Diagnostic Radiology
  
• 出版者：Springer Japan
• ISSN：1436-0691

文摘

We investigated the technical aspects of porcine abdominal multivisceral transplantation, in terms of pathophysiological features in animals given no immunosuppresant. The splanchnic organs of the donor animal were flushed in situ with University of Wisconsin solution via the abdominal aorta, using a pump. After a relatively short period of cold storage in saline, multivisceral grafts, including the liver, pancreas, and gastrointestinal tract, were transplanted orthotopically. Of the 18 recipient pigs that underwent the operation, 9 (50%) died within 24 h, mainly because of respiratory insufficiency (n = 5) and circulatory shock (n = 3). Three animals (17%) were lost to acute renal failure between the second and fifth postoperative days. Six pigs (33%) survived for more than 1 week, and the causes of death in these animals were bowel obstruction (n = 1), pneumonia (n = 2), rejection of the intestinal graft (n = 2), and deterioration (n = 1). Although the results of this study were not satisfactory, abdominal multivisceral transplantation using pigs is practical and may lead to the possible resolution of various problems, in regard to the immunologic aspects and the interrelationship of transplanted complex organs.