Long term follow up and retrospective study on 533 gastric cancer cases

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• 作者：Wei-Juan Zeng (1)
  Wen-Qin Hu (2)
  Lin-Wei Wang (1)
  Shu-Guang Yan (2)
  Jian-Ding Li (3)
  Hao-Liang Zhao (4)
  Chun-Wei Peng (1)
  Gui-Fang Yang (1)
  Yan Li (1)
  
  1. Departments of Oncology & Pathology ; Zhongnan Hospital of Wuhan University ; Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center ; Wuhan ; 430071 ; China
  2. Department of Surgery ; Heji Hospital Affiliated to Changzhi Medical College ; Changzhi ; 046000 ; China
  3. Department of Medical Imaging ; The First Affiliated Hospital of Shanxi Medical University ; No 85 ; South Jiefang Road ; Taiyuan City ; 030001 ; Shangxi Province ; China
  4. Department of General Surgery ; Shanxi University Hospital ; No 99 ; Longcheng Street ; Taiyuan City ; 046000 ; Shangxi Province ; China
  
• 关键词：Gastric cancer ; GC ; specific overall survival ; Prognosis ; Multivariate analysis ; Clinical pathological factors
• 刊名：BMC Surgery
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：14
• 期：1
• 全文大小：323 KB
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  39. The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2482/14/29/prepub
  
• 刊物主题：Surgery; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2482

文摘

Background Gastric cancer (GC) is the third leading cause of cancer death in China and the outcome of GC patients is poor. The aim of the research is to study the prognostic factors of gastric cancer patients who had curative intent or palliative resection, completed clinical database and follow-up. Methods This retrospective study analyzed 533 GC patients from three tertiary referral teaching hospitals from January 2004 to December 2010 who had curative intent or palliative resection, complete clinical database and follow-up information. The GC-specific overall survival (OS) status was determined by the Kaplan-Meier method, and univariate analysis was conducted to identify possible factors for survival. Multivariate analysis using the Cox proportional hazard model and a forward regression procedure was conducted to define independent prognostic factors. Results By the last follow-up, the median follow-up time of 533 GC patients was 38.6 mo (range 6.9-100.9 mo), and the median GC-specific OS was 25.3 mo (95% CI: 23.1-27.4 mo). The estimated 1-, 2-, 3- and 5-year GC-specific OS rates were 78.4%, 61.4%, 53.3% and 48.4%, respectively. Univariate analysis identified the following prognostic factors: hospital, age, gender, cancer site, surgery type, resection type, other organ resection, HIPEC, LN status, tumor invasion, distant metastases, TNM stage, postoperative SAE, systemic chemotherapy and IP chemotherapy. In multivariate analysis, seven factors were identified as independent prognostic factors for long term survival, including resection type, HIPEC, LN status, tumor invasion, distant metastases, postoperative SAE and systemic chemotherapy. Conclusions Resection type, HIPEC, postoperative SAE and systemic chemotherapy are four independent prognostic factors that could be intervened for GC patients for improving survival.