A Synthetic Prostaglandin E1 Analog, Alprostadil Alfadex, Relaxes Sphincter of Oddi in Humans

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• 作者：Tatsuya Koshitani ; Tadashi Kodama ; Hideki Sato ; Junpei Takaaki ; Yoichi Imamura ; Keimei Kato ; Naoki Wakabayashi ; Kazuhiko Tokita and Shoji Mitsufuji
• 关键词：sphincter of Oddi ; manometry ; prostaglandin ; alprostadil alfadex
• 刊名：Digestive Diseases and Sciences
• 出版年：2002
• 出版时间：2002
• 年：2002
• 卷：47
• 期：1
• 页码：152-156
• 全文大小：66 KB

文摘

It is well established that prostaglandins (PGs) exert potent pharmacological actions on vascular and nonvascular smooth muscle, although their effects on the sphincter of Oddi (SO) remain to be elucidated. The aim of this study was to investigate the effect of PGE₁ on motility of the human SO. Twenty patients appearing for routine endoscopic retrograde cholangiopancreatography (ERCP) examination were studied. Each patient was randomly allocated to receive an intravenous infusion of normal saline (six patients), or alprostadil alfadex, a synthetic PGE₁ analog, at a dose of either 0.05 or 0.1 g/kg/min (seven patients for each condition). Endoscopic biliary manometry was done with a recording of basal SO pressure, amplitude of SO phasic contractions, and phasic contractile frequency before and 5 min after intravenous infusions, using a 4-French microtransducer catheter. There was no significant change in SO motor variables following application of normal saline. Alprostadil alfadex significantly decreased basal SO pressure at a dose of 0.05 g/kg/min, and significantly decreased all parameters at a dose of 0.1 g/kg/min. A synthetic PGE₁ analog, alprostadil alfadex, effectively inhibits motility of the human SO. This drug may be of clinical application as a SO-relaxing agent.