Gastric mixed adenoneuroendocrine carcinoma with thyroid transcription factor-1-positive neuroendocrine component

详细信息    查看全文

• 作者：Emi Yamaguchi ; Yoshitoshi Sato ; Takafumi Oe…
• 关键词：Gastric small cell carcinoma ; Gastric neuroendocrine carcinoma ; Gastric mixed adenoneuroendocrine carcinoma ; Thyroid transcription factor ; 1
• 刊名：Clinical Journal of Gastroenterology
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：8
• 期：2
• 页码：82-87
• 全文大小：1,432 KB
• 参考文献：1.Matsusaka T, Watanabe H, Enjoji M. Oat-cell carcinoma of the stomach. FukuokaIgakuZasshi. 1976;67:65-3.
  2.Kubota T, Ohyama S, Hiki N, et al. Endocrine carcinoma of the stomach: clinicopathological analysis of 27 surgically treated cases in a single institute. Gastric Cancer. 2012;15:323-0.View Article PubMed
  3.Matsui T, Kataoka M, Sugita Y, et al. A case of small cell carcinoma of the stomach. Hepatogastroenterology. 1997;44:156-0.PubMed
  4.Chiba N, Suwa T, Hori M, et al. Advanced gastric endocrine cell carcinoma with distant lymph node metastasis: a case report and cliniclpathological characteristics of the disease. Gastric Cancer. 2004;7:122-.View Article PubMed
  5.Yano Y, Maeura Y, Yamazaki K, et al. A case of neuroendocrine cell carcinoma. J Jpn Surg Assoc. 2003;64:352-.View Article
  6.Namikawa T, Kobayashi M, Okabayashi T, et al. Primary gastric small cell carcinoma: report of a case and review of the literature. Med Mol Morphol. 2005;38:256-1.View Article PubMed
  7.Ishida M, Sekine S, Fukagawa T, et al. Neuroendocrine carcinoma of the stomach. Morphologic and immunohistochemical characteristics and prognosis. Am J Surg Pathol. 2013;37:949-9.View Article PubMed
  8.Iwafuchi M, Watanabe H, Ishihara N, et al. Histopathologhy of carcinoid tumor and endocrine cell carcinoma in gastrointestinal tract (in Japanese). Clin Gastroenterol. 1990;5:1669-1.
  9.Nishikura K, Watanabe H, Iwafuchi M, et al. Carcinogenesis of gastric endocrine cell carcinoma: analysis of histopathology and p 53 gene alteration. Gastric Cancer. 2003;6:203-.View Article PubMed
  10.Matsui K, Jin XM, Kitagawa M, et al. Clinicopathologic features of neuroendocrine carcinomas of the stomach: appraisal of small cell and large cell variants. Arch Pathol Lab Med. 1998;122:1010-.PubMed
  11.Miguchi M, Iseki M, Shimatani K. Advanced gastric neuroendocrine carcinoma with an adenocarcinoma component. Case Rep Gastroneterol. 2012;6:52-.View Article
  12.Kou T, Takayama W, Nishimori T, et al. Curative operation of liver metastasis six months after total gastrectomy for early small cell carcinoma of the stomach. Jpn J Gastroenterol Surg. 2013;46:16-4.View Article
  13.Nakayama H, Ishida Y, Munetomo Y, et al. Two cases of gastric small cell carcinoma who survival over 2?years after curative gastrectomy and adjuvant chemotherapy. Jpn J Gastroenterol Surg. 2008;41:70-.View Article
  14.Akaike H, Hanamura T, Mitsui F, et al. A case of early gastric small cell carcinoma with micrometastasis of lymph node. J Jpn Surg Assoc. 2010;71:690-.View Article
  15.Hosokawa A, Shimada Y, Shirao K, et al. Long-term survivor of gastric small cell carcinoma. Hepatogastroenterology. 2004;51:1567-0.PubMed
  16.Hanada N, Inoue K, Osako T, et al. A case of partial response in liver metastatic lesion from gastric endocrine cell carcinoma treated with S-1. Jpn J Cancer Chemother. 2006;33:1143-.
  17.Ohhinata R, Iwasaki Y, Ohashi M, et al. A case of gastric endocrine cell carcinoma with liver metastases treated with S-1/CDDP. Jpn J Cancer Chem. 2010;37:2508-0.
  18.Tsushima T, Tsuji Y, Abe S, et al. A case of metastatic gastric endocrine cell carcinoma which could be curably resected after chemotherapy with S-1/CDDP. Jpn J Cancer Chemother. 2008;35:817-0.
  19.Fujita H, Shinohara H, Ohata S, et al. A case of gastric small cell carcinoma with a greater than 5-year survival after curative gastrectomy and adjuvant chemotherapy. J Jpn Surg Assoc. 2009;70:3565-0.View Article
  20.Agoff SN, Lamps LW, Philip AT, et al. Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary neuroendocrine tumors. Mod Pathol. 2000;13:238-2.View Article PubMed
  21.Lee H, Choi J, An JS, et al. The clinicopathological characteristics of gastrointestinal neuroendocrine tumors; an analysis of 65 cases. Korean J Pathol. 2007;41:149-7.
  22.Li AFY, Li ACH, Hsu CY, et al. Small cell carcinoma in gastrointestinal tract: immunohistochemical and clinicopathological features. J Clin Pathol. 2010;63:620-.View Article PubMed
  23.Yamamoto J, Ikeda S. Primary gastric small cell carcinoma diagnosed as a poorly differentiated adenocarcinoma based on preoperative examinations. J Jpn Surg Assoc. 2004;65:2652-.View Article
  24.Poiana C, Carsote M, Ardeleanu C, et al. The value of the immunohistochemistry in a case of gastric neuroendocrine tumor and thyroid metastasis. Rom J Morphol Embryol. 2011;52:187-2.PubMed
  25.Ishiwa N, Nakatani Y, Inayama Y, et al. Immunohistochemical study of thyroid transcription factor-1 expression in lung cancers. JJLC. 2001;41:45-.View Article
  26.Kazato K, Kobayashi S, Kin Y, et al. Gastric carcinoid with coexisting tubular adenocarcinoma in the same tumor, Report of a case. I to Cho (Stomach and Intestine). 1983;18:245-3.
  27.Yamashina M, Flinner RA. Concurrent occurrence of adenocarcinoma and carcinoid tumor in the stomach: a composite tumor of
• 作者单位：Emi Yamaguchi (1)
  Yoshitoshi Sato (1)
  Takafumi Oe (1)
  Takeshi Nishi (1)
  Makoto Koike (1)
  Yasuhito Kitakado (1)
  Kenji Takubo (1)
  
  1. Department of Surgery, Matsue Red Cross Hospital, 200 Horo-machi, Matsue, Shimane, 690-8506, Japan
  
• 刊物主题：Gastroenterology; Hepatology; Abdominal Surgery; Colorectal Surgery; Surgical Oncology;
• 出版者：Springer Japan
• ISSN：1865-7265

文摘

Small cell carcinoma of the stomach, which is considered synonymous with neuroendocrine carcinoma, is rare. We encountered a case of mixed adenoneuroendocrine carcinoma. Gastrointestinal endoscopy revealed a type 0 IIa?+?IIc lesion in the stomach. Biopsy suggested well-differentiated adenocarcinoma. Endoscopic submucosal dissection was performed and gastric cancer comprising both well to moderately differentiated adenocarcinoma within the mucous membrane and small cell carcinoma invading to the submucosa with accompanying vessel invasion was found. Mixed adenoneuroendocrine carcinoma was diagnosed and the small cell carcinoma was thyroid transcription factor-1 positive. No tumor lesions were apparent in other organs, so distal gastrectomy and lymph node dissection were performed. Lymph node metastases were not observed. The patient is currently alive without recurrence. Thyroid transcription factor-1-positive gastric neuroendocrine carcinoma is very rare, and the thyroid transcription factor-1-positive rate may contribute to the prediction of prognosis and treatment selection. Accumulation of cases is thus very important.