Biphasic effect of alcohol intake on the development of fatty liver disease

详细信息    查看全文

• 作者：Hirokazu Takahashi ; Masafumi Ono ; Hideyuki Hyogo…
• 关键词：Obesity ; NAFLD ; NASH ; Alcoholic ; Prevalence ; Ultrasonography
• 刊名：Journal of Gastroenterology
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：50
• 期：11
• 页码：1114-1123
• 全文大小：852 KB
• 参考文献：1.Bedogni G, Miglioli L, Masutti F, et al. Incidence and natural course of fatty liver in the general population: the Dionysos study. Hepatology. 2007;46:1387–91.CrossRef PubMed
  2.Pendino GM, Mariano A, Surace P, et al. Prevalence and etiology of altered liver tests: a population—based survey in a Mediterranean town. Hepatology. 2005;41:1151–9.CrossRef PubMed
  3.Ruhl CE, Everhart JE. Joint effects of body weight and alcohol on elevated serum alanine aminotransferase in the United States population. Clin Gastroenterol Hepatol. 2005;3:1260–8.CrossRef PubMed
  4.Bizzaro N, Tremolada F, Casarin C, et al. Serum alanine aminotransferase levels among volunteer blood donors: effect of sex, alcohol intake and obesity. Ital J Gastroenterol. 1992;24:237–41.PubMed
  5.Kondili LA, Taliani G, Cerga G, et al. Correlation of alcohol consumption with liver histological features in non–cirrhotic patients. Eur J Gastroenterol Hepatol. 2005;17:155–9.CrossRef PubMed
  6.Maher JJ. Alcoholic steatosis and steatohepatitis. Semin Gastrointest Dis. 2002;13:31–9.PubMed
  7.Zhou YJ, Li YY, Nie YQ, et al. Prevalence of fatty liver disease and its risk factors in the population of South China. World J Gastroenterol. 2007;13:6419–24.PubMedCentral CrossRef PubMed
  8.Bellentani S, Saccoccio G, Masutti F, et al. Prevalence of and risk factors for hepatic steatosis in Northern Italy. Ann Intern Med. 2000;132:112–7.CrossRef PubMed
  9.Michitaka K, Nishiguchi S, Aoyagi Y, et al. Etiology of liver cirrhosis in Japan: a nationwide survey. J Gastroenterol. 2010;45:86–94.CrossRef PubMed
  10.Suzuki A, Angulo P, St Sauver J, et al. Light to moderate alcohol consumption is associated with lower frequency of hypertransaminasemia. Am J Gastroenterol. 2007;102:1912–9.CrossRef PubMed
  11.Dunn W, Xu R, Schwimmer JB. Modest wine drinking and decreased prevalence of suspected non-alcoholic fatty liver disease. Hepatology. 2008;47:1947–54.CrossRef PubMed
  12.Gunji T, Matsuhashi N, Sato H, et al. Light and moderate alcohol consumption significantly reduces the prevalence of fatty liver in the Japanese male population. Am J Gastroenterol. 2009;104:2189–95.CrossRef PubMed
  13.Hiramine Y, Imamura Y, Uto H, et al. Alcohol drinking patterns and the risk of fatty liver in Japanese men. J Gastroenterol. 2011;46:519–28.CrossRef PubMed
  14.Miyake T, Kumagi T, Hirooka M, et al. Body mass index is the most useful predictive factor for the onset of nonalcoholic fatty liver disease: a community—based retrospective longitudinal cohort study. J Gastroenterol. 2013;48:413–22.CrossRef PubMed
  15.Sogabe M, Okahisa T, Hibino S, Yamanoi A. Usefulness of differentiating metabolic syndrome into visceral fat type and subcutaneous fat type using ultrasonography in Japanese males. J Gastroenterol. 2012;47:293–9.CrossRef PubMed
  16.Nishioji K, Sumida Y, Kamaguchi M, et al. Prevalence of and risk factors for non-alcoholic fatty liver disease in a non-obese Japanese population, 2011–2012. J Gastroenterol. 2015;50:95–108.CrossRef PubMed
  17.Eguchi Y, Hyogo H, Ono M, et al. Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective study. J Gastroenterol. 2012;47:586–95.CrossRef PubMed
  18.Tanaka K, Hyogo H, Ono M, et al. Upper limit of normal serum alanine aminotransferase levels in Japanese subjects. Hepatol Res. 2014;44:1196–207.CrossRef PubMed
  19.The World Medical Association, Inc. Declaration of Helsinki; Ethical principle for medical research involving human subject. Seoul: WMA General Assembly; 2008.
  20.Examination Committee of Criteria for ‘Obesity Disease’ in Japan; Japan Society for the Study of Obesity. New criteria for ‘obesity disease’ in Japan. Circ J. 2002;66:987–92.CrossRef
  21.Guy J, Peters MG. Liver disease in women: the influence of gender on epidemiology, natural history, and patient outcomes. Gastroenterol Hepatol (NY). 2013;9:633–9.
  22.Becker U, Deis A, Sorensen TI, et al. Prediction of risk of liver disease by alcohol intake, sex, and age: a prospective population study. Hepatology. 1996;23:1025–9.CrossRef PubMed
  23.Lieber CS. Gender differences in alcohol metabolism and susceptibility. In: Wilsnack RW, Wilsnack SC, editors. Gender and alcohol: individual and social perspectives. Piscataway: Rutgers Center of Alcohol Studies; 1997. p. 77–89.
  24.Nolen-Hoeksema S. Gender differences in risk factors and consequences for alcohol use and problems. Clin Psychol Rev. 2004;24:981–1010.CrossRef PubMed
  25.Frezza M, di PC, Pozzato G, Terpin M, Baraona E, Lieber CS. High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first–pass metabolism. N Engl J Med. 1990;322:95–9.CrossRef PubMed
  26.Ikejima K, Enomoto N, Iimuro Y, et al. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. Am J Physiol. 1998;274(4 pt 1):G669–76.PubMed
  27.Dixon JB, Bhathal PS, O’ Brien PE. Non-alcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology. 2001;121:91–100.CrossRef PubMed
  28.Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high–calorie diet. Nature. 2006;444:337–42.CrossRef PubMed
  29.Tomie Furuya D, Binsack R, Onishi ME, et al. Low ethanol consumption induces enhancement of insulin sensitivity in liver of normal rats. Life Sci. 2005;77:1813–24.CrossRef PubMed
  30.Schulze MB, Hoffmann K, Manson JE, et al. Dietary pattern, inflammation, and incidence of type 2 diabetes in women. Am J Clin Nutr. 2005;82:675–84.PubMedCentral PubMed
  31.Davies MJ, Baer DJ, Judd JT, et al. Effects of moderate alcohol intake on fasting insulin and glucose concentrations and insulin sensitivity in postmenopausal women: a randomized controlled trial. JAMA. 2002;287:2559–62.CrossRef PubMed
  32.Feng L, Gao L, Guan Q, et al. Long–term moderate ethanol consumption restore insulin sensitivity in high–fat–fed rats by increasing SLCA4 (GLUT4) in the adipose tissue by AMP–activated kinase activation. J Endocrinol. 2008;199:95–104.CrossRef PubMed
  33.Sierksma A, Patel H, Ouchi N, et al. Effect of moderate alcohol consumption on adiponectin, tumor necrosis factor–alpha, and insulin sensitivity. Diabetes Care. 2004;27:184–9.CrossRef PubMed
  34.Yang CM, Carlson GP. Effects of ethanol on glutathione conjugation in rat liver and lung. Biochem Pharmacol. 1991;41:923–9.CrossRef PubMed
  35.Guarino MP, Afonso RA, Raimundo N, et al. Hepatic glutathione and nitric oxide are critical for hepatic insulin sensitizing substance action. Am J Physiol Gastrointest Liver Physiol. 2003;284:G588–94.CrossRef PubMed
  36.Feng L, Han B, Wang R, et al. The frequency of daily ethanol consumption influences the effect of ethanol on insulin sensitivity in rats fed a high–fat diet. Br J Nutr. 2012;107:850–7.CrossRef PubMed
  37.Lopez-Garcia E, Guallar-Castillon P, Leon-Muñoz L, et al. Prevalence and determinants of metabolically healthy obesity in Spain. Atherosclerosis. 2013;231:152–7.CrossRef PubMed
  38.Xu YY, Bhavani K, Wands JR, et al. Ethanol inhibits insulin receptor substrate–1 tyrosine phosphorylation and insulin–stimulated neuronal thread protein gene expression. Biochem J. 1995;310:125–32.PubMedCentral CrossRef PubMed
  39.Bhavani K, de la Monte SM, Brown NV, et al. Effect of ethanol on p36 protein kinase substrate and insulin receptor substrate 1 expression and tyrosyl phosphorylation in human hepatocellular carcinoma cells. Alcohol Clin Exp Res. 1995;19:441–6.CrossRef PubMed
  40.Onishi Y, Honda M, Ogihara T, et al. Ethanol feeding induces insulin resistance with enhanced PI 3–kinase activation. Biochem Biophys Res Commun. 2003;303:788–94.CrossRef PubMed
  41.Lindtner C, Scherer T, Zielinski E, et al. Binge drinking induces whole–body insulin resistance by impairing hypothalamic insulin action. Sci Transl Med. 2013;5:170ra14.PubMedCentral CrossRef PubMed
  42.Yki-Järvinen H, Nikkilä EA. Ethanol decreases glucose utilization in healthy man. J Clin Endocrinol Metab. 1985;61:941–5.CrossRef PubMed
  43.Yki-Järvinen H, Koivisto VA, Ylikahri R, et al. Acute effects of ethanol and acetate on glucose kinetics in normal subjects. Am J Physiol. 1988;254:E175–80.PubMed
  44.O’Shea RS, Dasarathy S, McCullough AJ. Alcoholic liver disease. Am J Gastroenterol. 2010;105:14–32.CrossRef PubMed
  45.Mendenhall CL. Anabolic steroid therapy as an adjunct to diet in alcoholic hepatic steatosis. Am J Dig Dis. 1968;13:783–91.CrossRef PubMed
  
• 作者单位：Hirokazu Takahashi (1)
  Masafumi Ono (2)
  Hideyuki Hyogo (4)
  Chika Tsuji (1) (5)
  Yoichiro Kitajima (1) (5)
  Naofumi Ono (5)
  Takahisa Eguchi (5)
  Kazuma Fujimoto (1)
  Kazuaki Chayama (4)
  Toshiji Saibara (2)
  Keizo Anzai (1)
  Yuichiro Eguchi (3)
  
  1. Department of Internal Medicine, Saga Medical School, Saga, Japan
  2. Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi, Japan
  4. Department of Gastroenterology and Metabolism, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan
  5. Clinical Gastroenterology, Eguchi Hospital, Saga, Japan
  3. Division of Hepatology, Saga Medical School, Saga, Japan
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gastroenterology
  Oncology
  Surgical Oncology
  Hepatology
  Internal Medicine
  Colorectal Surgery
  
• 出版者：Springer Japan
• ISSN：1435-5922

文摘

Background Fatty liver is an important clinical feature not only in alcoholic and non-alcoholic fatty liver diseases, but in other chronic liver diseases as well. Our aim was to elucidate the effect and relationship between habitual alcohol intake and obesity in the development of fatty liver disease.