Central administration of p-hydroxyamphetamine produces a behavioral stimulant effect in rodents: evidence for the involvement of dopaminergic systems
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- 作者：Hiroshi Onogi ; Masato Hozumi ; Osamu Nakagawasai ; Yuichiro Arai ; Seiichiro Ishigaki ; Atsushi Sato ; Seiichi Furuta ; Fukie Niijima ; Koichi Tan-No and Takeshi Tadano
- 关键词：p ; Hydroxyamphetamine ; Dopamine ; Nucleus accumbens ; Locomotor activity
- 刊名：Psychopharmacology
- 出版年：2010
- 出版时间：February, 2010
- 年：2010
- 卷：208
- 期：2
- 页码：323-331
- 全文大小：238.3 KB
文摘
Rationale and objectives It is well-known that amphetamine induces increased locomotor activity in rodents. We previously found that intracerebroventricular (i.c.v.) administration of p-hydroxyamphetamine (p-OHA), an amphetamine metabolite, increases synaptic dopamine (DA) levels in the striatum. In the present study, we investigated the effect of p-OHA on locomotor activity in rodents.