Association between BoLA-DRB3 and somatic cell count in Holstein cattle from Argentina

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• 作者：L. R. Baltian (1)
  M. V. Ripoli (2)
  S. Sanfilippo (3)
  S. N. Takeshima (4)
  Y. Aida (4)
  G. Giovambattista (2) ggiovam@fcv.unlp.edu.ar
• 关键词：BoLA ; DRB3 – ; Mastitis – ; Resistance/susceptibility – ; Somatic cell count
• 刊名：Molecular Biology Reports
• 出版年：2012
• 出版时间：July 2012
• 年：2012
• 卷：39
• 期：7
• 页码：7215-7220
• 全文大小：173.0 KB
• 参考文献：1. Rupp R, Boichard D (2003) Genetics of resistance to mastitis in dairy cattle. Vet Res 34:671–688
  2. Chu MX, Ye SC, Qiao L, Wang JX, Feng T, Huang DW, Cao GL, Di R, Fang L, Chen GH (2011) Polymorphism of exon 2 of BoLA-DRB3 gene and its relationship with somatic cell score in Beijing Holstein cows. Mol Biol Rep [Epub ahead of print]
  3. Takeshima SN, Aida Y (2006) Structure function and disease susceptibility of the bovine major histocompatibility complex. Anim Sci 77(2):138–150
  4. Park YH, Joo YS, Park YJ, Moon JS, Kim SH, Kwon NH, Ahn JS, Davis WC, Davies CJ (2004) Characterization of lymphocyte subpopulations and major histocompatibility complex haplotypes of mastitis-resistant and susceptible cows. J Vet Sci 5(1):29–39
  5. Horton R, Wilming L, Rand V, Lovering RC, Bruford EA, Khodiyar VK, Lush MJ, Povey S, Talbot CC Jr, Wright MW, Wain HM, Trowsdale J, Ziegler A, Beck S (2004) Gene map of the extended human MHC. Nat Rev Genet 5(12):889–899
  6. D铆az S, Ripoli MV, Peral Garc铆a P, Giovambattista G (2010) Marcadores gen茅ticos para resistencia y susceptibilidad a enfermedades infecciosas en animales dom茅sticos. In: Giovambattista G, Peral Garcia P (eds) Gen茅tica de Animales Dom茅sticos Editorial. Inter-M茅dica, Ciudad Aut贸noma de Buenos Aires, pp 157–178
  7. Sharif S, Mallard BA, Sargeant JM (2000) Presence of glutamine at position 74 of pocket 4 in the BoLA-DR antigen binding groove is associated with occurrence of clinical mastitis caused by Staphylococcus species. Vet Immunol Immunopathol 76(3–4):231–238
  8. Rupp R, Hernandez A, Mallard BA (2007) Association of bovine leukocyte antigen (BoLA) DRB3.2 with immune response, mastitis, and production and type traits in Canadian Holsteins. J Dairy Sci 90(2):1029–1038
  9. Juliarena MA, Poli M, Sala L, Ceriani C, Gutierrez S, Dolcini G, Rodr铆guez EM, Mari帽o B, Rodr铆guez-Dubra C, Esteban EN (2008) Association of BLV infection profiles with alleles of the BoLA-DRB3.2 gene. Anim Genet 39(4):432–438
  10. Maillard JC, Chantal I, Berthier D, Thevenon S, Sidibe I, Razafindraibe H (2003) Molecular immunogenetics in susceptibility to bovine dermatophilosis: a candidate gene approach and a concrete field application. Ann N Y Acad Sci 969:92–96
  11. Stear MJ, Tierney TJ, Baldock FC, Brown SC, Nicholas FW, Rudder TH (1988) Class I antigens of the bovine major histocompatibility system are weakly associated with variation in faecal worm egg counts in naturally infected cattle. Anim Genet 19(2):115–122
  12. Stear MJ, Hetzel DJ, Brown SC, Gershwin LJ, Mackinnon MJ, Nicholas FW (1990) The relationships among ecto- and endoparasite levels, class I antigens of the bovine major histocompatibility system, immunoglobulin E levels and weight gain. Vet Parasitol 34(4):303–321
  13. Stear MJ, Nicholas FW, Brown SC, Holroyd RG (1989) Class I antigens of the bovine major histocompatibility system and resistance to the cattle tick (Boophilus microplus) assessed in three different seasons. Vet Parasitol 31(3–4):303–315
  14. Acosta-Rodriguez R, Alonso-Morales R, Balladares S, Flores-Aguilar H, Garcia-Vazquez Z, Gorodezky C (2005) Analysis of BoLA class II microsatellites in cattle infested with Boophilus microplus ticks: class II is probably associated with susceptibility. Vet Parasitol 127(3–4):313–321
  15. Lie O, Solbu H, Larsen HJ, Spooner RL (1986) Possible association of antibody responses to human serum albumin and (T,G)-A-L with the bovine major histocompatibility complex (BoLA). Vet Immunol Immunopathol 11(4):333–350
  16. Glass EJ, Oliver RA, Spooner RL (1990) Variation in T cell responses to ovalbumin in cattle: evidence for Ir gene control. Anim Genet 21:15–28
  17. Ellis SA, Holmes EC, Staines KA, Smith KB, Stear MJ, McKeever DJ, MacHugh ND, Morrison WI (1999) Variation in the number of expressed MHC genes in different cattle class I haplotypes. Immunogenetics 50:319–328
  18. Van Eijk MJ, Stewart-Haynes JA, Lewin HA (1992) Extensive polymorphism of the BoLA-DRB3 gene distinguished by PCR-RFLP. Anim Genet 23(6):483–496
  19. Takeshima SN, Matsumoto Y, Miyasaka T, Arainga-Ramirez M, Saito H, Onuma M, Aida Y (2011) A new method for typing bovine major histocompatibility complex class II DRB3 alleles by combining two established PCR sequence-based techniques. Tissue Antigens (in press)
  20. Miltiadou D, Law AS, Russell GC (2003) Establishment of a sequence-based typing system for BoLA-DRB3 exon 2. Tissue Antigens 62:55–65
  21. Takeshima SN, Matsumoto Y, Aida Y (2009) Establishment of a new polymerase chain reaction-sequence-based typing method for genotyping cattles major histocompatibility complex class II BRB3. J Dairy Sci 92(6):2965–2970
  22. Weir BS, Cockerham CC (1984) Estimating F-statistics for the analysis of populations structure. Evolution 3:1358–1370
  23. Gou SW, Thompsom EA (1992) Performing the exact test of Hardy–Weinberg proportion for multiple alleles. Biometrics 48:361–372
  24. Nei M (1987) Estimation of average heterozygosity and genetic distance from a small number of individuals. Genetics 89:583–590
  25. Raymond M, Rousset F (1995) GENEPOP (version 4.0): A population genetics software for exact test and ecumenicism. J Hered 86:248–249
  26. Thursz MR, Thomas HC, Greenwood BM, Hill AV (1997) Heterozygote advantage for HLA class-II type in hepatitis B virus infection. Nat Genet 17:11–12
  27. Hraber P, Kuiken C, Yusim K (2007) Evidence for human leukocyte antigen heterozygote advantage against hepatitis C virus infection. Hepatology 46:1713–1721
  28. Takeshima SN, Matsumoto Y, Chen J, Yoshida T, Mukoyama H, Aida Y (2008) Evidence for cattle major histocompatibility complex (BoLA) class II DQA1 gene heterozygote advantage against clinical mastitis caused by Streptococci and Escherichia species. Tissue Antigens 72:525–531
  29. Sharif S, Mallard BA, Wilkie BN (1998) Associations of the bovine major histocompatibility complex DRB3 (BoLA-DRB3) with production traits in Canadian dairy cattle. Anim Genet 30(2):157–160
  30. Dietz AB, Cohen ND, Timms L, Kehrli ME Jr (1997) Bovine lymphocyte antigen class II alleles as risk factors for high somatic cell counts in milk of lactating dairy cows. J Dairy Sci 80(2):406–412
  31. Kelm S, Detilleux A, Freeman A, Kelm S, Detilleux A, Freeman A, Kehrli J, Dietz A, Fox L, Butler J, Kasckovics I, Kelly D (1997) Genetic association between parameters of innate immunity and measures of mastitis in periparturient Holstein cattle. J Dairy Sci 80:1767–1775
  32. Kullberg S, Heringstad B, Guttersrud OA, Olsaker I (2007) Study on the association BoLA-DRB3.2 alleles with clinical mastitis in Norwegian Red cows. J Anim Breed Genet 124:201–207
  33. Starkenburg RJ, Hansen LB, Kehrli JR, Chester-Jones J (1997) Frequencies and effects of alternative DRB3.2 alleles of bovine lymphocyte antigen for Holsteins in milk selection and control line. J Dairy Sci 80:3411–3419
  34. Yoshida T, Mukoyama H, Furuta H, Kondo Y, Takeshima SN, Aida Y, Kosugiyama M, Tomogane H (2009) Association of the amino acid motifs of BoLA-DRB3 alleles with mastitis pathogens in Japanese Holstein cows. Anim Sci 80(5):510–519
  35. Yoshida T, Mukoyama H, Furuta H, Kondo Y, Takeshima SN, Aida Y, Kosugiyama M, Tomogane H (2009) Association of BoLA-DRB3 alleles identified by a sequence-based typing method with mastitis pathogens in Japanese Holstein cows. Anim Sci 80(5):498–509
• 作者单位：1. Dpto de Producci贸n, FCV, UNLPam, Calle 116 esq. 5, 6360 General Pico, LP, Argentina2. IGEVET 鈥?CCT LA PLATA 鈥?CONICET, FCV, UNLP, B1900AVW, CC 296, La Plata, Argentina3. Dpto de Ciencias Basicas, FCV, UNLPam, Calle 116 esq. 5, 6360 General Pico, LP, Argentina4. Viral Infectious Diseases Unit, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Animal Anatomy, Morphology and Histology
  Animal Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-4978

文摘

Different studies have proved that the resistance/susceptibility to mastitis is genetically determined. The major histocompatibility complex in cows is known as bovine lymphocyte antigen (BoLA). Genes from the BoLA have been associated with the occurrence of infectious diseases such as mastitis and leukosis, especially the BoLA-DRB gene. The object of the present study was to detect associations between BoLA-DRB3 alleles and somatic cell count (SCC), as an indicator of resistance/susceptibility to mastitis in Holstein cattle (N = 123) from La Pampa, Argentina. Fisher’s exact test and Woolf–Haldane odds ratio were applied to study the association between SCC and BoLA-DRB3 allele frequencies. Significant association was noted between BoLA-DRB3.2*23 and *27 alleles (p < 0.05) and protective or susceptibility effects, respectively. In addition, alleles BoLA-DRB3.2*20 and *25 exhibit suggestive association with high SCC (p < 0.1). These results were partially in agreement with data reported from Japanese Holstein cattle, but differed from those published by other authors. A possible explanation for the contrasting results could be that the mastitis is a multifactor disease caused by different pathogens. Moreover, most of the studies were carried out using PCR-RFLP method, which has less resolution than PCR-SBT because PCR-RFLP defined alleles included more than one sequenced alleles.