Induced pluripotent stem cells in reproductive medicine

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• 作者：Takeshi Teramura (1) (2)
  John Frampton (3)
  
• 关键词：Germ cells ; Induced pluripotent stem cells ; In vitro differentiation ; Pluripotency ; Reprogramming
• 刊名：Reproductive Medicine and Biology
• 出版年：2013
• 出版时间：April 2013
• 年：2013
• 卷：12
• 期：2
• 页码：39-46
• 全文大小：275KB
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• 作者单位：Takeshi Teramura (1) (2)
  John Frampton (3)
  
  1. Institute of Advanced Clinical Medicine, Kinki University Faculty of Medicine, 377-2 Osaka-sayama, Osaka, Japan
  2. Department of Obstetrics and Gynecology, Mie University Faculty of Medicine, Tsu, Mie, Japan
  3. Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA
  

文摘

Despite recent advances in reproductive medicine, there are still no effective treatments for severe infertility caused by congenital absence of germ cells or gonadotoxic treatments during prepubertal childhood. However, the development of technologies for germ cell formation from stem cells in vitro, induction of pluripotency from somatic cells, and production of patient-specific pluripotent stem cells may provide new solutions for treating these severe fertility problems. It may be possible to produce germ cells in vitro from our own somatic cells that can be used to restore fertility. In addition, these technologies may also bring about novel therapies by helping to elucidate the mechanisms of human germ cell development. In this review, we describe the current approaches for obtaining germ cells from pluripotent stem cells, and provide basic information about induction of pluripotency and germ cell development.