Determinants of plasma brain natriuretic peptide levels in untreated hypertensive patients
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- 作者：Akiko Goda (1)
Shinji Nakao (1)
Takeshi Tsujino (1)
Masao Yuba (1)
Misato Otsuka (1)
Mika Matsumoto (1)
Chikako Yoshida (1)
Yoshiro Naito (1)
Masaaki Lee-Kawabata (1)
Mitsumasa Ohyanagi (2)
Tohru Masuyama (1) - 关键词：Hypertension ; BNP ; Hypertrophy ; LV diastolic function ; Echocardiography
- 刊名：Journal of Echocardiography
- 出版年：2011
- 出版时间：September 2011
- 年：2011
- 卷：9
- 期：3
- 页码：103-108
- 全文大小：400KB
- 参考文献：1. Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med. 1990;31:1561-. CrossRef
2. Park JB, Schiffrin EL. Small artery remodeling is the most prevalent (earliest?) form of target organ damage in mild essential hypertension. J Hypertens. 2001;19:921-0. CrossRef
3. Oishi Y, Mizuguchi Y, Miyoshi H, Iuchi A, Nagase N, Oki T. Echocardiographic features of patients with congestive heart failure and preserved left ventricular pump function: a retrospective study in a selected common disease cohort. J Echocardiogr. 2008;6:9-4. CrossRef
4. Cowie MR, Struthers AD, Wood DA, Coats AJ, Thompson SG, Poole-Wilson PA, et al. Value of natriuretic peptides in assessment of patients with possible new heart failure in primary care. Lancet. 1997;350:1349-3. CrossRef
5. Troughton RW, Frampton CM, Yandle TG, Espiner EA, Nicholls MG, Richards AM. Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentrations. Lancet. 2000;355:1126-0. CrossRef
6. Kohno M, Horio T, Yokokawa K, Murakawa K, Yasunari K, Akioka K, et al. Brain natriuretic peptide as a cardiac hormone in essential hypertension. Am J Med. 1992;92:29-4. CrossRef
7. Suzuki M, Hamada M, Yamamoto K, Kazatani Y, Hiwada K. Brain natriuretic peptide as a risk marker for incident hypertensive cardiovascular events. Hypertens Res. 2002;25:669-6. CrossRef
8. Sahn DJ, DeMaria A, Kisslo J, Weyman A. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation. 1978;58:1072-3.
9. Shigematsu Y, Hamada M, Mukai M, Matsuoka H, Sumimoto T, Hiwada K. Clinical evidence for an association between left ventricular geometric adaptation and extracardiac target organ damage in essential hypertension. J Hypertens. 1995;13:155-0. CrossRef
10. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18:1440-3. CrossRef
11. Ganau A, Devereux RB, Roman MJ, de Simone G, Pickering TG, Saba PS, et al. Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension. J Am Coll Cardiol. 1992;19:1550-. CrossRef
12. Teicholz LE, Kreulen T, Herman MV, Gorlin R. Problems in echocardiographic volume determination: echocardiographic–angiographic correlations in the presence or absence of asynergy. Am J Cardiol. 1976;37:7-2. CrossRef
13. Wallerson DC, Ganau A, Roman MJ, Devereux RB. Measurement of cardiac output by M-mode and two-dimensional echocardiography: application to patients with hypertension. Eur Heart J. 1990;11(Suppl I):67-8.
14. Nishikimi T, Yoshihara F, Morimoto A, Ishikawa K, Ishimitsu T, Saito Y, et al. Relationship between left ventricular geometry and natriuretic peptide levels in essential hypertension. Hypertension. 1996;28:22-0.
15. Nakao S, Goda A, Yuba M, Otsuka M, Matsumoto M, Yoshida C, et al. Characterization of left ventricular filling abnormalities and its relation to elevated plasma brain natriuretic peptide level in acute to chronic diastolic heart failure. Circ J. 2000;71:12-. - 作者单位：Akiko Goda (1)
Shinji Nakao (1)
Takeshi Tsujino (1)
Masao Yuba (1)
Misato Otsuka (1)
Mika Matsumoto (1)
Chikako Yoshida (1)
Yoshiro Naito (1)
Masaaki Lee-Kawabata (1)
Mitsumasa Ohyanagi (2)
Tohru Masuyama (1)
1. Department of Internal Medicine, Cardiovascular Division, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, 663-8501, Japan
2. Department of Internal Medicine, Division of Coronary Heart Disease, Hyogo College of Medicine, Nishinomiya, Japan
文摘
Background Plasma brain natriuretic peptide (BNP) level is elevated in patients with left ventricular (LV) hypertrophy reflecting not only altered LV geometry but LV systolic and/or diastolic dysfunction. However, the values and limitations of BNP measurements are unclear in patients with untreated hypertension. In this study, plasma BNP level was compared with LV geometric and functional characteristics in patients with untreated hypertension. Methods Plasma BNP level was measured in 115 patients with untreated hypertension (72 males, 43 females, aged 60?±?12?years). Routine echo parameters of LV geometry and LV systolic and diastolic performance were also determined. Results LV ejection fraction was 67?±?6% and plasma BNP level was 32?±?30?pg/ml. Plasma BNP levels correlated with age, LV mass index (LVMI), and mitral E velocity, respectively (r?=?0.46, p?<?0.05; r?=?0.21, p?<?0.05; r?=?0.29, p?<?0.05, respectively), but not with systolic blood pressure or relative wall thickness (r?=?0.01; r?=??.02). Plasma BNP level correlated with E/E-/em> ratio (r?=?0.27, p?<?0.05, n?=?77). When a stepwise multivariate analysis was performed, E velocity was selected in addition to age and LVMI as significant correlates of plasma BNP level. Conclusions LVMI and E velocity were independent determinants of plasma BNP level in patients with untreated hypertension. Plasma BNP level is substantially useful for the screening of abnormalities of LV geometry and/or function in patients with untreated hypertension. Additional echocardiography is useful to assess the mechanism of the elevation of plasma BNP level in untreated hypertensive patients.