Long-term Heat Exposure Prevents Hypoxia-Induced Apoptosis in Mouse Fibroblast Cells

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• 作者：Naotoshi Sugimoto (1) (2)
  Osamu Shido (2)
  Kentaro Matsuzaki (2)
  Masanori Katakura (2)
  Yoshiaki Hitomi (3)
  Masao Tanaka (4)
  Toshioki Sawaki (4)
  Yoshimasa Fujita (4)
  Takafumi Kawanami (4)
  Yasufumi Masaki (4)
  Toshiro Okazaki (4)
  Hiroyuki Nakamura (3)
  Shoichi Koizumi (5)
  Akihiro Yachie (6)
  Hisanori Umehara (4)
  
• 关键词：Heat acclimation ; Heat shock proteins ; HIF ; 1α ; Heat tolerance ; Cross tolerance
• 刊名：Cell Biochemistry and Biophysics
• 出版年：2014
• 出版时间：September 2014
• 年：2014
• 卷：70
• 期：1
• 页码：301-307
• 全文大小：656 KB
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• 作者单位：Naotoshi Sugimoto (1) (2)
  Osamu Shido (2)
  Kentaro Matsuzaki (2)
  Masanori Katakura (2)
  Yoshiaki Hitomi (3)
  Masao Tanaka (4)
  Toshioki Sawaki (4)
  Yoshimasa Fujita (4)
  Takafumi Kawanami (4)
  Yasufumi Masaki (4)
  Toshiro Okazaki (4)
  Hiroyuki Nakamura (3)
  Shoichi Koizumi (5)
  Akihiro Yachie (6)
  Hisanori Umehara (4)
  
  1. Department of Physiology, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8640, Japan
  2. Department of Environmental Physiology, School of Medicine, Shimane University, Izumo, Japan
  3. Department of Public Health, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
  4. Department of Hematology and Immunology, Kanazawa Medical University, Uchinada, Japan
  5. United Graduate School of Child Development, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
  6. Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
  
• ISSN：1559-0283

文摘

Long-term continuous exposure to high ambient temperatures induces complete heat acclimation in humans and animals. However, to date, the effects of long-term exposure to heat stress on cells have not been fully evaluated. In this study, we investigated an adaptive physiological process induced in culture cells by continuous exposure to mild heat stress for 60?days. The results of this investigation provide evidence that after long-term heat acclimation in cells, (1) heat shock protein levels are increased, (2) hypoxia inducible factor-1α (HIF-1α) expression is upregulated, and (3) heat shock-induced and hypoxia-induced apoptoses are attenuated. These results suggest that the hypoxia response pathway is an intrinsic part of the heat acclimation repertoire and that the HIF-1 pathway following long-term heat acclimation induces cells with cross tolerance against hypoxia.