Chlorpromazine-induced perturbations of bile acids and free fatty acids in cholestatic liver injury prevented by the Chinese herbal compound Yin-Chen-Hao-Tang
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- 作者：Qiaoling Yang ; Fan Yang ; Xiaowen Tang…
- 关键词：Bile acids ; Free fatty acids ; Chlorpromazine ; Yin ; Chen ; Hao ; Tang (YCHT) ; UPLC–MS ; Hepatoprotective effect
- 刊名：BMC Complementary and Alternative Medicine
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：15
- 期：1
- 全文大小：1,665 KB
- 刊物主题：Complementary & Alternative Medicine; Internal Medicine; Chiropractic Medicine;
- 出版者：BioMed Central
- ISSN：1472-6882
文摘
Backgrounds Yin-Chen-Hao-Tang (YCHT), a commonly used as a traditional chinese medicine for liver disease. Several studies indicated that YCHT may improving hepatic triglyceride metabolism and anti-apoptotic response as well as decreasing oxidative stress .However, little is known about the role of YCHT in chlorpromazine (CPZ) –induced chlolestatic liver injury. Therefore, we aimed to facilitate the understanding of the pathogenesis of cholestatic liver injury and evaluate the effect of Yin-Chen-Hao-Tang (YCHT) on chlorpromazine (CPZ)-induced cholestatic liver injury in rats based on the change of bile acids (BAs) and free fatty acids (FFAs) alone with the biochemical indicators and histological examination.