Angiotensin converting enzyme inhibiting therapy is associated with lower vitreous vascular endothelial growth factor concentrations in patients with proliferative diabetic retinopathy
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- 作者：I. M. Hogeboom van Buggenum ; B. C. P. Polak ; J. W. M. Reichert-Thoen ; W. A. E. J. de Vries-Knoppert ; V. W. M. van Hinsbergh and G. J. Tangelder
- 关键词：Keywords Angiotensin ; converting enzyme inhibitors ; vascular endothelial growth factor ; diabetic retinopathy ; diabetes mellitus ; enalapril ; antihypertensive agents ; patients.
- 刊名：Diabetologia
- 出版年：2002
- 出版时间：February 2002
- 年：2002
- 卷：45
- 期：2
- 页码：203-209
- 全文大小：94 KB
文摘
Aims/hypothesis: Vascular endothelial growth factor (VEGF) is thought to be instrumental in the progression of diabetic retinopathy. Indications exist that the renin-angiotensin system is involved in VEGF overexpression. We assessed the vitreous VEGF concentrations in patients and related them to anti-hypertensive treatment, with special interest in the use of ACE-inhibitors.