New onset neuromyelitis optica in a young Nigerian woman with possible antiphospholipid syndrome: a case report

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• 作者：Morenikeji A Komolafe (1)
  Edward O Komolafe (2)
  Taofiki A Sunmonu (1)
  SO Olateju (2)
  CM Asaleye (3)
  Olufemi A Adesina (1)
  SA Badmus (2)
  
• 刊名：Journal of Medical Case Reports
• 出版年：2008
• 出版时间：December 2008
• 年：2008
• 卷：2
• 期：1
• 全文大小：297KB
• 参考文献：1. Wingerchuk DM, Lennon VA, Lucchinetti CF, Pittock SJ, Weinshenker BG: The spectrum of neuromyelitis optica. / Lancet Neurol 2007,6(9):805鈥?15. CrossRef
  2. Wingerchuk DM, Hogencamp WF, O'Brien PC, Weinshenker BG: The clinical course of neuromyelitis optica (Devic's syndrome). / Neurology 1999,53(5):1107鈥?114.
  3. Wingerchuk DM, Lucchinetti CF: Comparative immunopathogenesis of acute disseminated encephalomyelitis, neuromyelitis optica, and multiple sclerosis. / Curr Opin Neurol 2007,20(3):343鈥?50. CrossRef
  4. Jacob A, Matiello M, Wingerchuk DM, Lucchinetti CF, Pittock SJ, Weinshenker BG: Neuromyelitis optica: Changing concepts. / J Neuroimmunol 2007,187(1鈥?):126鈥?38. CrossRef
  5. Weinshenker BG, Wingerchuk DM, Pittock SJ, Lucchinetti CF, Lennon VA: NMO-IgG 鈥?a specific biomarker for NMO. / Dis Markers 2006,22(4):197鈥?06.
  6. Matiello M, Jacob A, Wingerchuk DM, Weinshenker BG: Neuromyelitis optica. / Curr Opin Neurol 2007,20(3):25鈥?6. CrossRef
  7. Osuntokun BO: The pattern of neurological illness in tropical Africa, experience at Ibadan Nigeria. / J Neurol Sci 1971,12(4):417鈥?42. CrossRef
  8. Vasonnenberg E, April S: A case of Neuromyelitis Optica (Devic's syndrome) in systemic lupus erythematosus. / Neurology 1976,28(11):1066鈥?070.
  9. Mandler RN, Davies LE, Jeffery DR, Kornfeild M: Devic's NMO: A clinicopathological study of 8 patients. / Ann Neurol 1993,34(2):162鈥?68. CrossRef
  10. Tezzon F, Tomelleri P, Ferrari G, Sergi A: Acute radiculomyelitis after antitetanus vaccination. / Ital J Neurol 1994,15(4):191鈥?93. CrossRef
  11. Jacobi C, Stingele K, Kretz R, Hartmann M, Storch-Hagenlocher B, Breitbart A, Wildemann B: Neuromyelitis optica (Devic's syndrome) as first manifestation of systemic lupus erythematosus. / Lupus 2006,15(2):107鈥?09. CrossRef
  
• 作者单位：Morenikeji A Komolafe (1)
  Edward O Komolafe (2)
  Taofiki A Sunmonu (1)
  SO Olateju (2)
  CM Asaleye (3)
  Olufemi A Adesina (1)
  SA Badmus (2)
  
  1. Department of Medicine, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria
  2. Department of Surgery, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria
  3. Department of Radiology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria
  

文摘

Introduction Devic's neuromyelitis optica is an inflammatory demyelinating disease that targets the optic nerves and spinal cord. It has a worldwide distribution and distinctive features that distinguish it from multiple sclerosis. There has been no previous report of neuromyelitis optica from our practice environment, and we are not aware of any case associated with antiphospholipid syndrome in an African person. Case presentation We report the case of a 28-year-old Nigerian woman who presented with neck pain, paroxysmal tonic spasms, a positive Lhermitte's sign and spastic quadriplegia. She later developed bilateral optic neuritis and had clinical and biochemical features of antiphospholipid syndrome. Her initial magnetic resonance imaging showed a central linear hyperintense focus in the intramedullary portion of C2 to C4. Repeat magnetic resonance imaging after treatment revealed resolution of the signal intensity noticed earlier. Conclusion Neuromyelitis optica should be considered in the differential diagnoses of acute myelopathy in Africans. We also highlight the unusual association with antiphospholipid syndrome. Physicians should screen such patients for autoimmune disorders.