Probing the intermolecular interactions of PPARγ-LBD with polyunsaturated fatty acids and their anti-inflammatory metabolites to infer most potential binding moieties
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- 作者：Shalini Muralikumar ; Umashankar Vetrivel…
- 关键词：PPARγ ; PUFA ; Bioactive lipids ; Docking ; Helix12
- 刊名：Lipids in Health and Disease
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：16
- 期：1
- 全文大小：1924KB
- 刊物主题：Lipidology; Medical Biochemistry; Clinical Nutrition;
- 出版者：BioMed Central
- ISSN：1476-511X
- 卷排序：16
文摘
BackgroundPPARγ is an isoform of peroxisome proliferator-activated receptor (PPAR) belonging to a super family of nuclear receptors. PPARγ receptor is found to play a crucial role in the modulation of lipid and glucose homeostasis. Its commotion has been reported to play a significant role in a broad spectrum of diseases such as type 2 diabetes mellitus, inflammatory diseases, Alzheimer’s disease, and in some cancers. Hence, PPARγ is an important therapeutic target. Polyunsaturated fatty acids (PUFAs) and their metabolites (henceforth referred to as bioactive lipids) are known to function as agonists of PPARγ. However, agonistic binding modes and affinity of these ligands to PPARγ are yet to be deciphered.