Genetic and clinical profile of Indian patients of idiopathic restrictive cardiomyopathy with and without hypertrophy
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- 作者：Taranjit Singh Rai ; Shamim Ahmad ; Tarunveer Singh Ahluwalia ; Monica Ahuja ; Ajay Bahl ; Uma Nahar Saikia ; Balvinder Singh ; Kewal K. Talwar and Madhu Khullar
- 关键词：Restrictive cardiomyopathy ; Hypertrophic cardiomyopathy ; MYH7 ; TNNI3 ; Mutations
- 刊名：Molecular and Cellular Biochemistry
- 出版年：2009
- 出版时间：November, 2009
- 年：2009
- 卷：331
- 期：1-2
- 页码：187-192
- 全文大小：277.3 KB
文摘
Both idiopathic restrictive cardiomyopathy (IRCM) and hypertrophic cardiomyopathy (HCM) are part of the same disease spectrum and are due to sarcomeric gene mutations. A patient with restrictive physiology without left ventricular hypertrophy (LVH) would be diagnosed as IRCM, while one with LVH would be diagnosed as HCM with restrictive physiology. We studied a group of patients with restrictive physiology for mutations in beta-myosin heavy chain (MYH7) and troponin I (TNNI3) gene. Consecutive probands in the HCM and IRCM cohort over a 4-year period were considered for this study. These included 10 IRCM and 102 HCM patients. All were Asian Indians. Among the 17 patients who had restrictive physiology 10 were IRCM patients and seven were HCM patients. Of the HCM patients, seven (6.9 % ) had restrictive physiology. Mean age of these 17 patients was 40.1 ¡À 19.2 years (range: 15–67 ), six (35.3 % ) were males. Maximal left ventricular wall thickness of the seven HCM probands was 20.7 ¡À 5.2 mm (range: 16–31), while it was normal in the IRCM probands. Ten probands (58.8 % ) were in NYHA class III or IV. Seven patients (41.2 % ) had atrial fibrillation. All the probands were screened for mutations in selected exons of MYH7 and TNNI3 genes. One IRCM patient was found to have p.Arg721Lys mutation in the MYH7 gene. She died due to progressive congestive cardiac failure at the age of 47 years. One HCM proband with a maximal left ventricular wall thickness of 17 mm had p.Arg192His mutation in the TNNI3 gene. She had features consistent with restrictive physiology. Her father and sister had died of restrictive cardiomyopathy. IRCM and HCM with restrictive physiology, both are part of the clinical expression of MYH7 and TNNI3 mutations and lead to worse clinical onset and progression of the disease.