Effects of docetaxel on antigen presentation-related functions of human monocyte-derived dendritic cells
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- 作者：Hiroshi Nakashima ; Akira Tasaki ; Makoto Kubo ; Hideo Kuroki ; Kotaro Matsumoto ; Masao Tanaka ; Masafumi Nakamura ; Takashi Morisaki and Mitsuo Katano
- 关键词：Taxane ; Non ; directional migration ; Directional migration ; Microtubules ; Immunotherapy
- 刊名：Cancer Chemotherapy and Pharmacology
- 出版年：2005
- 出版时间：May 2005
- 年：2005
- 卷：55
- 期：5
- 页码：479-487
- 全文大小：386 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Cancer Research
Pharmacology and Toxicology
Oncology - 出版者：Springer Berlin / Heidelberg
- ISSN：1432-0843
文摘
Purpose Docetaxel (TXT) is a unique chemotherapeutic agent that has been approved for treating various types of malignancies. TXT stabilizes microtubule assembly in cells and causes various dysfunctions of microtubule-dependent cellular events. Patients with advanced malignancies are beginning to receive TXT in combination with immunotherapy; however, the influence of TXT at clinically achievable serum concentrations (less than 10–6 M) on antigen presentation-related functions of human monocyte-derived dendritic cells (Mo-DCs) remains unclear.